青少年行为问题与遗传、环境因素关系的双生子研究

发布时间：2019-02-16 13:38

【摘要】：目的:探讨青少年行为问题与遗传、环境因素的相关性。方法:选择重庆市12~18岁66对青少年双生子,采用Achenbach青少年自评量表(Youth Self-Report,YSR)测查行为问题,采集双生子静脉血标本,提取DNA进行卵型鉴定。根据同卵双生子间表型相关系数(rMZ)和异卵双生子间表型相关系数(rDZ)的比较,进行遗传效应的粗约估计,构建结构方程模型(SEM),定量分析加性遗传因素(A)、共享环境因素(C)、特殊环境因素(E)与青少年行为问题的关系。结果:社交问题及违纪行为rMZrDZ,提示数据不适合进行遗传分析;其余各因子rMZ、rDZ比较:退缩行为、躯体主诉、焦虑/抑郁情绪、攻击行为、思维问题、注意问题因子rMZ2rDZ,均拟合ACE模型。其最优模型均为AE模型。在遗传效应(A)及个体特异性环境(E)总变异方差中,焦虑/抑郁情绪、攻击行为因子遗传效应在0.52~0.57之间,个体特异性环境在0.43~0.48之间;退缩行为、躯体主诉、思维问题及注意问题遗传效应在0.17~0.45之间,个体特异性环境在0.55~0.83之间。结论:青少年社交问题及违纪行为与遗传效应关系不明显;退缩行为、躯体主诉、焦虑/抑郁情绪、思维问题、注意问题、攻击行为与加性遗传因素及个体特异性环境因素均有相关性;焦虑/抑郁、攻击行为与遗传因素相关程度大,其余因子均与个体特异性环境因素相关度大。
[Abstract]:Objective: to explore the correlation between behavioral problems and genetic and environmental factors in adolescents. Methods: two pairs of twins aged 12 ~ 18 years old in Chongqing were selected. Behavior problems were examined by Achenbach Youth Self-Rating scale (Youth Self-Report,YSR). Venous blood samples of twins were collected and DNA was extracted for egg type identification. Based on the comparison of phenotypic correlation coefficients (rMZ) between identical twins and heterozygote twins (rDZ), rough reduction estimation of genetic effects was made, and structural equation model (SEM),) was constructed for quantitative analysis of additive genetic factors (A),). The relationship between shared environmental factor (C), special environmental factor (E) and adolescent behavior problems. Results: rMZrDZ, data of social problems and disciplinary violations were not suitable for genetic analysis. RMZ,rDZ comparison of other factors: withdrawal behavior, body complaint, anxiety / depression, aggressive behavior, thinking problem, attention problem factor rMZ2rDZ, all fit ACE model. The optimal models are all AE models. In the total variance of genetic effect (A) and individual specific environment (E), the genetic effects of anxiety / depression and aggressive behavior factors ranged from 0.52 to 0.57, and from 0.43 to 0.48 for individual specific environment. The genetic effects of withdrawal behavior, body complaints, thinking problems and attention problems ranged from 0.17 to 0.45, and from 0.55 to 0.83. Conclusion: there is no obvious relationship between social problems and behaviors against discipline and genetic effects in adolescents. Withdrawal behavior, body complaints, anxiety / depression, thinking problems, attention problems, aggressive behavior and additive genetic factors and individual specific environmental factors were correlated. Anxiety / depression, aggressive behavior and genetic factors were highly correlated, and other factors were highly correlated with individual specific environmental factors.
【作者单位】：重庆医科大学附属第一医院护理学院;重庆医科大学附属第一医院心理卫生中心;四川大学华西医院心理卫生中心;
【分类号】：C913.5;;Q351

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