上海市居民小麦粉中脱氧雪腐镰刀菌烯醇及其乙酰衍生物的暴露评估

发布时间：2019-04-12 07:52

【摘要】：目的了解上海市居民经小麦粉摄入的脱氧雪腐镰刀菌烯醇(DON)及其乙酰衍生物3-乙酰基-脱氧雪腐镰刀菌烯醇(3-Ac-DON)和15-乙酰基-脱氧雪腐镰刀菌烯醇(15-Ac-DON)的暴露总量。方法利用高效液相色谱-串联质谱法对2011~2013年上海市售小麦粉中DON、3-Ac-DON、15-Ac-DON的含量分别进行检测,计算三者的总量。并结合上海市居民小麦粉摄入数据,以该化合物组的暂定每日最大耐受摄入量(PMTDI)1μg/(kg BW·d)为参考,对上海市居民经小麦粉摄入的DON及其乙酰衍生物的暴露总量分别进行点评估和概率评估。结果 (1)点评估显示,对于受到DON及其乙酰衍生物不同水平污染(均数、P50、P75、P90和P95)的小麦粉,人群在小麦粉均数和P50摄入水平时,毒素暴露总量皆低于PMTDI(占其18%~83%),而在小麦粉P95摄入水平时,毒素暴露总量皆高于PMTDI(为其1.08~2.55倍)。(2)概率评估显示,总人群、小麦粉食用人群和15岁人群通过小麦粉摄入的DON及其乙酰衍生物的暴露总量低于PMTDI概率分别为89.99%、87.00%和76.55%。结论随着小麦粉摄入量的增高,上海市居民的DON及其乙酰衍生物的暴露风险增高;多数人摄入小麦粉是安全的,但有10.01%的人群处于风险状态,其中15岁人群是DON及其乙酰衍生物暴露的高危人群。
[Abstract]:Objective to understand the (DON) of deoxynivalenol and its derivatives, 3-acetyl-deoxynivalenol (3-Ac-DON) and 15-acetyl-deoxynivalenol (15-acetyl-deoxynivalenol), which were ingested by wheat flour in Shanghai residents. Total exposure to mycorrhizal (15-Ac-DON). Methods High performance liquid chromatography (HPLC)-tandem mass spectrometry (HPLC-MS) was used to determine the content of DON,3-Ac-DON,15-Ac-DON in wheat flour sold in Shanghai from 2011 to 2013, and the total amount of them was calculated. Based on the data of wheat flour intake of Shanghai residents, the tentative daily maximum tolerance intake of (PMTDI) 1 渭 g / (kg BW 路d for the compound group was used as a reference. The total exposure amount of DON and acetyl derivatives ingested by wheat flour in Shanghai residents was evaluated by point assessment and probability assessment respectively. Results (1) Point assessment showed that for wheat flour contaminated with different levels of DON and its acetyl derivatives (mean, P50, P75, P90 and P95), the population was exposed to the average of wheat flour and P50 intake levels of wheat flour at different levels of contamination (mean, P50, P75, P90 and P95). The total amount of toxin exposure was lower than that of PMTDI (18% / 83%), but at the intake level of wheat flour P95, the total amount of toxin exposure was higher than that of PMTDI (1.08% / 2.55 times). (2). The total exposure probability of DON and acetyl derivatives ingested by wheat flour was 89.99%, 87.00% and 76.55% respectively in wheat flour consuming population and 15-year-old population. Conclusion with the increase of wheat flour intake, the exposure risk of DON and its acetyl derivatives increased in Shanghai residents. Most people are safe to consume wheat flour, but 10.01% of the population is at risk, including 15-year-old people who are at high risk of exposure to DON and its acetyl derivatives.
【作者单位】：复旦大学公共卫生学院营养与食品卫生学教研室公共卫生安全教育部重点实验室;上海市食品药品监督所;
【基金】：上海市科学技术委员会科技支撑项目(No.13391901402)
【分类号】：R155.5

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