谷物膳食纤维对脂代谢紊乱小鼠肝脏脂毒性影响

发布时间：2019-04-12 07:13

【摘要】：目的观察不同类型谷物膳食纤维(DF)对脂代谢紊乱小鼠血脂和肝脏脂毒性影响。方法 48只雄性C57BL/6J小鼠(6周龄)按体重随机分为4组:对照组、模型组、燕麦DF组、小麦DF组,连续干预24周,实验期间每周称体重并记录摄食量,每8周内眦静脉采血,进行血脂和血糖连续动态观察;干预结束后测定空腹血糖、血清总胆固醇(TC)、甘油三酯(TG)和游离脂肪酸(FFAs)及肝组织TG含量。结果与对照组比较,模型组小鼠体重[(37.69±2.66)g]、空腹血糖[(8.21±2.06)mmol/L]、血清TC、TG、FFAs水平[分别为(2.69±0.45)、(1.77±0.64)mmol/L、(2.12±0.38)m Eq/L]明显升高(P0.05);与模型组比较,燕麦DF与小麦DF组小鼠体重[分别为(34.41±2.93)、(34.43±1.72)g]、血清TC、TG水平[分别为(2.03±0.44)、(2.22±0.50)与(1.64±0.43)、(1.39±0.41)mmol/L]均明显下降(P0.05);燕麦DF组小鼠血清FFAs水平[(1.75±0.49)m Eq/L]明显降低(P0.05)。结论谷物DF可以改善脂代谢紊乱小鼠血脂和肝脏脂毒性,燕麦DF改善血脂和肝脏脂毒性的作用优于小麦DF。
[Abstract]:Objective to observe the effects of different types of cereal dietary fiber (DF) on lipid and liver lipid toxicity in mice with lipid metabolism disorder. Methods 48 male C57BL/6J mice (6 weeks old) were randomly divided into 4 groups: control group, model group, oat DF group and wheat DF group. Continuous dynamic observation of blood lipid and blood glucose was carried out. Fasting blood glucose, serum total cholesterol (TC), triglyceride (TG) (TG), free fatty acid (FFAs) (FFA) and liver tissue TG (TG) were measured at the end of intervention. Results compared with the control group, the body weight [(37.69 卤2.66) g], fasting blood glucose [(8.21 卤2.06) mmol/L] and serum TC,TG,FFAs level [(2.69 卤0.45), (1.77 卤0.64) mmol/L,] in the model group [(2.69 卤0.45), (1.77 卤0.64 mmol/L, respectively]. (2.12 卤0.38) m Eq/L increased significantly (P0.05); Compared with the model group, the body weight of oat DF and wheat DF group [(34.41 卤2.93), (34.43 卤1.72) g], the serum TC,TG level [(2.03 卤0.44), (2.22 卤0.50) and (1.64 卤0.43), respectively]. (1.39 卤0.41) mmol/L decreased significantly (P0.05); The serum FFAs level in oat DF group [(1.75 卤0.49) m Eq/L] was significantly decreased (P0.05). Conclusion Grain DF can improve blood lipid and liver lipid toxicity in mice with lipid metabolism disorder. Oat DF has better effect on improving lipid and liver lipid toxicity than wheat DF..
【作者单位】：苏州大学医学部公共卫生学院营养与食品卫生学系;
【基金】：国家自然科学基金(81302425) 江苏省自然科学基金(BK20130334) 江苏省博士后科研资助计划(1302014A)
【分类号】：R151

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