尘肺病患者经纤维支气管镜大容量肺灌洗残余量预测模型初探

发布时间：2019-04-14 18:19

【摘要】：[目的]通过建立尘肺病患者经纤维支气管镜大容量肺灌洗残余量预测模型,为筛选尘肺肺灌洗对象及初步预测灌洗疗效提供参考。[方法]收集238例尘肺病患者,经纤维支气管镜大容量肺灌洗术,分析残余量与患者病情分期、灌洗量、肺功能、身高、体重、体质指数的关系,建立多元线性回归模型,筛选影响灌洗残余量的主要影响因素。[结果]经纤维支气管镜大容量肺灌洗术中残余量与病情分期无关,不同期别尘肺灌洗量及残余量比较,差异无统计学意义(P0.05),灌洗量、用力肺活量(FVC%)及50%肺活量最大呼气流量(MEF50)是残余量的影响因素。[结论]本研究建立的经纤维支气管镜大容量肺灌洗残余量预测模型,可初步筛选肺灌洗病人并预测肺灌洗疗效。
[Abstract]:[objective] to establish a prediction model of large volume lung lavage residue in pneumoconiosis patients through fiberoptic bronchoscopy, so as to provide reference for screening pneumoconiosis lavage objects and initially predicting the curative effect of lavage. [methods] 238 cases of pneumoconiosis were treated with large volume lung lavage with fiberoptic bronchoscope. The relationship between the residual volume and the stage, the amount of lavage, the lung function, height, body weight and body mass index were analyzed, and the multiple linear regression model was established. The main factors affecting the residual amount of lavage were screened. [results] there was no significant difference in the volume of lavage and residual volume of pneumoconiosis between different stages (P0.05), and there was no significant difference between the residual volume of bronchofiberscope and the stage of the disease (P0.05), but there was no significant difference in the amount of lavage between different stages of pneumoconiosis (P0.05). Forced vital capacity (FVC%) and maximal expiratory flow (MEF50) of 50% vital capacity were the influencing factors of residual volume. [conclusion] the predictive model of large volume lung lavage residue established by fiberoptic bronchoscopy can be used to screen patients with lung lavage and predict the therapeutic effect of lung lavage.
【作者单位】：湖南省职业病防治院职业病科;
【基金】：湖南省科技厅重点科研项目(编号:2011WS2020)
【分类号】：R135.2

【参考文献】