孕期分阶段营养补充剂对孕鼠繁殖能力和体质的影响
发布时间：2019-06-04 21:20
【摘要】：目的:探讨分阶段给予孕期营养补充剂对雌鼠妊娠、哺乳阶段体质及繁殖能力的影响。方法:以成年雌鼠为研究对象,按人体推荐日摄入量计算,以等效剂量的0.5倍、1倍、2倍分为低、中、高3个剂量组为实验组,于妊娠第1天开始分别连续6d灌胃,补充孕早期、孕中期、孕晚期3种营养补充剂;以等量溶媒安慰剂灌胃为溶媒对照组,以正常孕鼠为正常对照组;对比观察母鼠妊娠期、哺乳期的体重和血红蛋白水平(HGB)变化及繁殖能力。结果:实验各组母鼠妊娠期、哺乳期,以及离乳1周的体重除分娩次日外均高于对照组(P0.05);HGB也较对照组增高(P0.05),高剂量组除孕晚期外均较对照组有极显著差异(P0.01);实验各组胚胎总数和正常胚胎数与对照组无统计学差异(P0.05),但中剂量组和高剂量组异常胚胎数明显减少(P0.05);高剂量组产仔数高于对照组(P0.05),哺乳21d中剂量组仔鼠存活率较对照组明显增加(P0.05);离乳1周仔鼠存活率中剂量组较对照组明显增加(P0.05)。结论:孕期分阶段给予营养补充剂可增强雌鼠妊娠期和哺乳期体质,提高其繁殖能力。
[Abstract]:Objective: to investigate the effect of nutritional supplement during pregnancy on the physique and reproductive ability of female rats during pregnancy and lactation. Methods: adult female mice were divided into low, middle and high dose groups according to the recommended daily intake of human body. The rats were given intragastrically for 6 days from the first day of pregnancy. Three kinds of nutritional supplements were supplemented in the early pregnancy, the second trimester and the third trimester of pregnancy. Using the same amount of placebo as solvent control group and normal pregnant rats as normal control group, the changes of body weight and hemoglobin level (HGB) and reproductive ability of female rats during pregnancy and lactation were compared. Results: the body weight of the female rats in each group during pregnancy, lactation and 1 week out of milk was higher than that in the control group except the day after delivery (P 0.05). HGB was also higher in the high dose group than in the control group (P 0.05), except in the third trimester of pregnancy, there was significant difference between the high dose group and the control group (P 0.01). There was no significant difference in the total number of embryos and the number of normal embryos between the experimental group and the control group (P 0.05), but the number of abnormal embryos in the middle dose group and the high dose group decreased significantly (P 0.05). The litter size of the high dose group was higher than that of the control group (P 0.05), the survival rate of the middle dose group was significantly higher than that of the control group (P 0.05), and the survival rate of the middle dose group was significantly higher than that of the control group (P 0.05). Conclusion: nutritional supplements during pregnancy can enhance the physique of female mice during pregnancy and lactation and improve their reproductive ability.
【作者单位】： 北京协和医学院研究生院;国家卫生计生委科学技术研究所;
【分类号】：R153.1
，
本文编号：2493011
[Abstract]:Objective: to investigate the effect of nutritional supplement during pregnancy on the physique and reproductive ability of female rats during pregnancy and lactation. Methods: adult female mice were divided into low, middle and high dose groups according to the recommended daily intake of human body. The rats were given intragastrically for 6 days from the first day of pregnancy. Three kinds of nutritional supplements were supplemented in the early pregnancy, the second trimester and the third trimester of pregnancy. Using the same amount of placebo as solvent control group and normal pregnant rats as normal control group, the changes of body weight and hemoglobin level (HGB) and reproductive ability of female rats during pregnancy and lactation were compared. Results: the body weight of the female rats in each group during pregnancy, lactation and 1 week out of milk was higher than that in the control group except the day after delivery (P 0.05). HGB was also higher in the high dose group than in the control group (P 0.05), except in the third trimester of pregnancy, there was significant difference between the high dose group and the control group (P 0.01). There was no significant difference in the total number of embryos and the number of normal embryos between the experimental group and the control group (P 0.05), but the number of abnormal embryos in the middle dose group and the high dose group decreased significantly (P 0.05). The litter size of the high dose group was higher than that of the control group (P 0.05), the survival rate of the middle dose group was significantly higher than that of the control group (P 0.05), and the survival rate of the middle dose group was significantly higher than that of the control group (P 0.05). Conclusion: nutritional supplements during pregnancy can enhance the physique of female mice during pregnancy and lactation and improve their reproductive ability.
【作者单位】： 北京协和医学院研究生院;国家卫生计生委科学技术研究所;
【分类号】：R153.1
，
本文编号：2493011
本文链接：https://www.wllwen.com/yixuelunwen/yufangyixuelunwen/2493011.html
