特种甘薯TSP-1水提物对Ⅱ型糖尿病大鼠血脂和血小板的影响
发布时间：2019-06-25 16:44
【摘要】：用高脂饲料连续喂养12周后结合一次性腹腔注射链脲佐菌素(streptozotocin,STZ)20 mg/kg建立Ⅱ型糖尿病(typeⅡdiabetes mellitus,T2DM)大鼠模型。在造模后继续饲喂高脂饲料的过程中用TSP-1甘薯水提物干预治疗,以生理盐水作为对照。结果表明,TSP-1甘薯水提物连续灌胃给药5周后,T2DM模型大鼠血液总胆固醇(TC)显著降低(P0.05)、甘油三酯(TG)及动脉粥样硬化指数(AI)极显著降低(P0.01),而血小板数量显著增加;TSP-1甘薯水提物并不能阻止T2DM模型大鼠血糖值的继续升高,但与对照组相比增幅下降,两者差异不显著(P0.05),表明TSP-1甘薯水提物不能有效降低T2DM模型大鼠血糖。
[Abstract]:A model of type II diabetes mellitus (type II diabetes mellitus, T2DM) was established after 12 weeks of continuous feeding with high-fat feed and 20 mg/ kg of streptozoocin (STZ)20 mg/ kg. In the process of feeding high-fat feed, the water extract of TSP-1 sweet potato was used for the treatment and the normal saline was used as the control. The results showed that the total cholesterol (TC) decreased significantly (P0.05), triglyceride (TG) and atherosclerosis index (AI) in the model rats with T2DM (P0.05), while the number of platelets increased significantly after 5 weeks of continuous gastric administration of TSP-1 sweet potato water extract. The water extract of the TSP-1 sweet potato could not prevent the continuous increase of the blood glucose level in the model rats of the T2DM model, but the difference between the two groups was not significant (P0.05), indicating that the water extract of the TSP-1 sweet potato could not effectively reduce the blood sugar of the rats with T2DM.
【作者单位】： 江苏徐淮地区徐州农业科学研究所;中国农业科学院甘薯研究所;
【基金】：国家现代农业产业技术体系建设专项资金(编号:CARS-11-B-20)
【分类号】：TS201.4;R151
[Abstract]:A model of type II diabetes mellitus (type II diabetes mellitus, T2DM) was established after 12 weeks of continuous feeding with high-fat feed and 20 mg/ kg of streptozoocin (STZ)20 mg/ kg. In the process of feeding high-fat feed, the water extract of TSP-1 sweet potato was used for the treatment and the normal saline was used as the control. The results showed that the total cholesterol (TC) decreased significantly (P0.05), triglyceride (TG) and atherosclerosis index (AI) in the model rats with T2DM (P0.05), while the number of platelets increased significantly after 5 weeks of continuous gastric administration of TSP-1 sweet potato water extract. The water extract of the TSP-1 sweet potato could not prevent the continuous increase of the blood glucose level in the model rats of the T2DM model, but the difference between the two groups was not significant (P0.05), indicating that the water extract of the TSP-1 sweet potato could not effectively reduce the blood sugar of the rats with T2DM.
【作者单位】： 江苏徐淮地区徐州农业科学研究所;中国农业科学院甘薯研究所;
【基金】：国家现代农业产业技术体系建设专项资金(编号:CARS-11-B-20)
【分类号】：TS201.4;R151
【参考文献】
中国期刊全文数据库 前7条
1 付慧;汪秋宽;何云海;任丹丹;;多肋藻渣膳食纤维对小鼠降血脂作用的研究[J];大连海洋大学学报;2012年03期
2 陈q，
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