焦炉作业工人尿中多环芳烃代谢物与肺功能下降的关联性研究
发布时间：2019-06-27 13:37
【摘要】：目的：研究焦炉作业工人尿中多环芳烃（polycyclic aromatic hydrocarbons，PAHs）代谢物与肺功能下降的关联，为进一步阐明焦炉工人早期肺部损伤机制以及制订预防职业性肺损伤的策略提供科学依据。 方法：检测环境中一氧化碳、二氧化硫、苯可溶物、颗粒物及颗粒物上载带PAHs的浓度，采用问卷调查和健康体检的方式收集武汉某焦化厂912名工人的职业信息和健康情况，工人按照外环境检测结果和职业史分为办公室人群（对照组）和焦炉作业工人（暴露组）。收集工人的清晨尿液，用气相色谱-质谱联用仪检测尿中10种PAHs代谢物，并采用肺功能分析仪检测工人的肺功能。 结果：焦炉作业工人长期暴露于高浓度的COEs中，而办公室区域的COEs水平相对较低，据此，我们将焦炉作业人群定义为暴露组，办公人群定义为对照组。尽管暴露组的平均年龄和工龄均小于对照组，但其肺功能均低于对照组，差异有统计学意义。接着，，我们根据工人的职业史，计算了工人在焦炉作业的时间，即焦炉作业时间，没有在焦炉工作的时间即为无焦炉作业时间。结果显示，在暴露组中，腰臀比与FEV1%的负关联有显著性，并且随焦炉作业时间的增加，FEV1/FVC%降低的趋势也具有显著性（β=㧟0.156）。在对照组中，FEV1%和FEV1/FVC%与年龄和吸烟包年的关联有显著性差异。然后，我们讨论了尿中PAHs代谢物与肺功能的关联，将暴露组PAHs代谢产物的蓄积作用定义为PAHs代谢物浓度与焦炉作业时间的乘积，对照组PAHs代谢物的蓄积作用定义为PAHs代谢物浓度与无焦炉作业时间的乘积。在暴露组中，OHPh和1-OHP的蓄积作用均显示和FEV1/FVC%的负关联具有显著性差异（β=㧟0.136，β=㧟0.100），并且OHPh和1-OHP相加作用的蓄积作用也显示和FEV1/FVC%呈负关联（β=㧟0.127），P值均小于0.05，而在对照组中，PAHs代谢物的蓄积作用均无统计学意义。 结论：焦炉作业工人尿中PAHs代谢物与肺功能下降相关联，提示长期暴露于职业性PAHs引起工人肺部早期损伤，并且PAHs中的菲和芘有可能是引起焦炉工肺部早期损伤的主要物质。
[Abstract]:Objective: to study the relationship between urinary polycyclic aromatic hydrocarbons (polycyclic aromatic hydrocarbons,PAHs) metabolites and decreased lung function in coke oven workers, and to provide scientific basis for further elucidating the mechanism of early lung injury in coke oven workers and formulating strategies to prevent occupational lung injury. Methods: the concentrations of carbon monoxide, sulfur dioxide, benzene soluble matter, particulate matter and particulate matter carrying PAHs in the environment were measured. The occupational information and health status of 912 workers in a coking plant in Wuhan were collected by questionnaire and physical examination. According to the results of external environment test and occupational history, the workers were divided into office population (control group) and coke oven workers (exposure group). The early morning urine of workers was collected, 10 kinds of PAHs metabolites in urine were detected by gas chromatography-mass spectrometry (GC-MS), and the pulmonary function of workers was detected by pulmonary function analyzer. Results: coke oven workers were exposed to high concentration of COEs for a long time, but the COEs level in office area was relatively low. According to this, we defined coke oven workers as exposure group and office population as control group. Although the average age and length of service of the exposed group were lower than those of the control group, the pulmonary function of the exposed group was lower than that of the control group, and the difference was statistically significant. Then, according to the occupational history of the workers, we calculate the working time of the workers in the coke oven, that is, the working time of the coke oven, and the time of not working in the coke oven is the time without the coke oven. The results showed that there was a significant negative correlation between waist hip ratio and FEV1% in the exposed group, and the decrease trend of FEV1/FVC% was also significant with the increase of coke oven operation time (尾 = 0.156). In the control group, there were significant differences between FEV1% and FEV1/FVC% and age and smoking age. Then, we discussed the relationship between PAHs metabolites in urine and lung function. The accumulation of PAHs metabolites in exposure group was defined as the product of PAHs metabolite concentration and coke oven operation time, and the accumulation of PAHs metabolites in control group was defined as the product of PAHs metabolite concentration and coke oven operation time. In the exposure group, the accumulation of OHPh and 1-OHP was significantly different from that of FEV1/FVC% (尾 = 0.136, 尾 = 0.100), and the accumulation of OHPh and 1-OHP was negatively correlated with FEV1/FVC% (尾 = 0.127), P value was less than 0.05, but there was no significant difference in the accumulation of PAHs metabolites in the control group. Conclusion: PAHs metabolites in urine of coke oven workers are associated with decreased lung function, suggesting that long-term exposure to occupational PAHs may cause early lung injury in workers, and phenanthrene and pyrene in PAHs may be the main substances causing early lung injury in coke oven workers.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R131
本文编号：2506838
[Abstract]:Objective: to study the relationship between urinary polycyclic aromatic hydrocarbons (polycyclic aromatic hydrocarbons,PAHs) metabolites and decreased lung function in coke oven workers, and to provide scientific basis for further elucidating the mechanism of early lung injury in coke oven workers and formulating strategies to prevent occupational lung injury. Methods: the concentrations of carbon monoxide, sulfur dioxide, benzene soluble matter, particulate matter and particulate matter carrying PAHs in the environment were measured. The occupational information and health status of 912 workers in a coking plant in Wuhan were collected by questionnaire and physical examination. According to the results of external environment test and occupational history, the workers were divided into office population (control group) and coke oven workers (exposure group). The early morning urine of workers was collected, 10 kinds of PAHs metabolites in urine were detected by gas chromatography-mass spectrometry (GC-MS), and the pulmonary function of workers was detected by pulmonary function analyzer. Results: coke oven workers were exposed to high concentration of COEs for a long time, but the COEs level in office area was relatively low. According to this, we defined coke oven workers as exposure group and office population as control group. Although the average age and length of service of the exposed group were lower than those of the control group, the pulmonary function of the exposed group was lower than that of the control group, and the difference was statistically significant. Then, according to the occupational history of the workers, we calculate the working time of the workers in the coke oven, that is, the working time of the coke oven, and the time of not working in the coke oven is the time without the coke oven. The results showed that there was a significant negative correlation between waist hip ratio and FEV1% in the exposed group, and the decrease trend of FEV1/FVC% was also significant with the increase of coke oven operation time (尾 = 0.156). In the control group, there were significant differences between FEV1% and FEV1/FVC% and age and smoking age. Then, we discussed the relationship between PAHs metabolites in urine and lung function. The accumulation of PAHs metabolites in exposure group was defined as the product of PAHs metabolite concentration and coke oven operation time, and the accumulation of PAHs metabolites in control group was defined as the product of PAHs metabolite concentration and coke oven operation time. In the exposure group, the accumulation of OHPh and 1-OHP was significantly different from that of FEV1/FVC% (尾 = 0.136, 尾 = 0.100), and the accumulation of OHPh and 1-OHP was negatively correlated with FEV1/FVC% (尾 = 0.127), P value was less than 0.05, but there was no significant difference in the accumulation of PAHs metabolites in the control group. Conclusion: PAHs metabolites in urine of coke oven workers are associated with decreased lung function, suggesting that long-term exposure to occupational PAHs may cause early lung injury in workers, and phenanthrene and pyrene in PAHs may be the main substances causing early lung injury in coke oven workers.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R131
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