计算机辅助诊断在肝脏灌注中的应用

发布时间：2018-04-02 13:23

本文选题：灌注成像　切入点：计算机辅助诊断　出处：《西安电子科技大学》2013年硕士论文

【摘要】：随着科技的进步，CT灌注成像在疾病诊疗方面发挥着日趋重要的作用。CT灌注成像是从组织细胞和微循环水平来评估组织的生理病理状态，是医学图像处理领域的热点之一。近年来，CT灌注成像在头部的应用日益成熟，但在肝脏中的应用却发展缓慢。因为肝脏具有复杂的双重供血系统，与CT头部灌注成像相比，CT肝脏灌注成像更为困难。本文的目的是开发一套针对CT肝脏灌注的CAD软件，该软件可计算各项肝脏灌注参数，，并生成功能图像，从而提高医生对肝脏疾病的诊断质量和诊断效率。本文主要做了以下几方面工作：首先，介绍了灌注成像的基本原理，以及几种灌注的数学模型和灌注成像的主要参数。其次，研究并实现三种计算肝脏灌注参数的算法，并嵌入研发的CT肝脏灌注CAD软件中。此外，在常规的双输入模型算法的基础上，提出了相应的改进方法，并与原双输入法和斜率法进行了比较。结果表明，改进后的算法比原算法计算灌注参数更为精确，与较为稳定的斜率法计算出的参数有很好的一致性。最后，使用一组真实的肝癌CT数据和一组正常肝脏CT数据来对所研发的软件进行测试，结果表明，软件的所有算法均可使肝癌病灶部分在功能图像上更为突出的显示出来，且操作方便，能够辅助医生对肝脏病变进行检测。
[Abstract]:With the development of science and technology, CT perfusion imaging plays an increasingly important role in the diagnosis and treatment of diseases. Ct perfusion imaging is a hot spot in the field of medical image processing, which is to evaluate the physiological and pathological status of tissues from the level of tissue cells and microcirculation.In recent years, the application of CT perfusion imaging in the head is becoming more and more mature, but the application in the liver is slow.Because the liver has a complex dual blood supply system, CT perfusion imaging is more difficult than CT perfusion imaging.The purpose of this paper is to develop a set of CAD software for CT liver perfusion. The software can calculate the parameters of hepatic perfusion and generate functional images, thus improving the quality and efficiency of diagnosis of liver diseases by doctors.The main work of this paper is as follows: firstly, the basic principle of perfusion imaging, several mathematical models of perfusion and the main parameters of perfusion imaging are introduced.Secondly, three algorithms for calculating liver perfusion parameters are studied and implemented, and embedded into CT liver perfusion CAD software.In addition, based on the conventional double input model algorithm, the corresponding improved method is proposed and compared with the original double input method and slope method.The results show that the improved algorithm is more accurate than the original algorithm in calculating the perfusion parameters and is in good agreement with the parameters calculated by the more stable slope method.Finally, a set of real liver cancer CT data and a set of normal liver CT data are used to test the developed software. The results show that all the algorithms of the software can make the liver cancer focus more prominent on the functional images.And the operation is convenient, can assist the doctor to carry on the examination to the liver disease.
【学位授予单位】：西安电子科技大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：TP391.72;R816.5

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