指骨骨密度和膝骨关节炎相关性的影像学评价

发布时间：2018-06-17 13:20

本文选题：骨关节炎 + 膝　；参考：《中国组织工程研究》2015年20期

【摘要】：背景:骨关节炎和骨质疏松症是与人体衰老相关的两大退行性疾病,国内外针对其相关性的研究较多,但至今仍未得出统一结论。目的:通过横断面研究探讨影像学膝骨关节炎和指骨骨密度的相关性。方法:纳入2 855名研究对象,同时测量骨密度和双膝正位片,对潜在的混杂因素进行校正,应用多变量的Logistic回归分析模型来评估影像学膝骨关节炎和指骨骨密度的相关性。结果与结论:校正因素包括性别、年龄、体质量指数、吸烟、饮酒、总能量摄入量、平均钙摄入量、营养素补充剂和钙补充剂摄入量等,发现影像学膝骨关节炎和指骨骨密度呈正相关。在女性亚组中,这一相关性仍然成立,男性亚组则不具有相关性。证实在女性人群中膝骨关节炎和指骨骨密度的正相关性,提示骨密度可能为膝骨关节炎的保护因素。
[Abstract]:Background: osteoarthritis and osteoporosis are two major degenerative diseases related to human aging. Objective: to investigate the correlation between knee osteoarthritis and phalangeal bone mineral density (BMD) by cross-sectional study. Methods: the bone mineral density (BMD) and bone mineral density (BMD) were measured in 2 855 subjects. The potential confounding factors were corrected. The correlation between imaging osteoarthritis and phalangeal bone mineral density was evaluated by multivariate logistic regression model. Results & conclusion: sex, age, body mass index, smoking, alcohol consumption, total energy intake, average calcium intake, nutrient supplement and calcium supplement intake were adjusted. A positive correlation was found between osteoarthritis of knee and bone density of phalanx. This correlation remains true in female subgroups, but not in male subgroups. The positive correlation between knee osteoarthritis and phalanx bone mineral density was confirmed in female population, suggesting that bone mineral density may be the protective factor of knee osteoarthritis.
【作者单位】：中南大学湘雅医院骨科;
【基金】：中南大学研究生自主创新项目(2014zzts347)~~
【分类号】：R684.3;R816.8

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