大强度间歇训练预防高脂饮食大鼠非酒精性脂肪性肝病的形成

发布时间：2018-07-10 07:28

本文选题：大强度间歇训练 + 非酒精性脂肪性肝病　；参考：《中国运动医学杂志》2015年09期

【摘要】：目的:研究大强度间歇运动训练预防大鼠非酒精性脂肪性肝病(NAFLD)模型形成的效果。方法:雄性Wistar大鼠随机分为四组:正常饮食安静组(9只,普通饲料喂养),高脂饮食安静组(9只,高脂饲料喂养),高脂饮食运动组(14只,高脂饲料喂养同时大强度运动干预),正常饮食运动组(15只,普通饲料喂养同时大强度运动干预)。8周后处死,观察各组大鼠肝脏形态,比较各组肝细胞脂肪变性程度、肝重、血脂等指标的变化。结果:高脂饮食安静组大鼠肝脏为灰黄色,肝细胞呈广泛脂肪变性,其变性程度、肝脏重量、血清总胆固醇和低密度脂蛋白均高于正常饮食安静组(P0.01或0.05),高密度脂蛋白低于正常饮食安静组(P0.05);高脂饮食运动组肝脏为红褐色,肝细胞脂肪变性程度、肝脏重量、血清总胆固醇和甘油三酯均低于高脂饮食安静组(P0.01或0.05);正常饮食运动组的肝脏脂肪变性程度与正常饮食安静组差异无统计学意义(P0.05),但肝重、血清总胆固醇和甘油三酯均显著低于正常饮食安静组(P0.01或0.05)。结论:大强度间歇训练可以有效预防高脂饮食形成的NAFLD。
[Abstract]:Aim: to study the effect of high intensity intermittent exercise training on preventing the formation of NAFLD model in rats. Methods: male Wistar rats were randomly divided into four groups: normal diet quiet group (9 rats), high fat diet group (14 rats), high fat diet group (9 rats) and high fat diet group (14 rats). The rats were killed in normal diet exercise group (15 rats) after 8 weeks of high fat diet feeding and high intensity exercise intervention. The liver morphology of each group was observed, and the degree of fatty degeneration and liver weight of liver cells in each group were compared. Changes of serum lipids and other indexes. Results: the liver of the rats in the quiet group of high fat diet was grayish yellow, the liver cells showed extensive fatty degeneration, the degree of degeneration and the weight of the liver. Serum total cholesterol and low density lipoprotein were higher than normal diet quiet group (P0.01 or 0.05), high density lipoprotein was lower than normal diet quiet group (P0.05), liver of high-fat diet exercise group was reddish brown, liver cell fat degeneration degree, liver weight, Serum total cholesterol and triglyceride were lower than those of the quiet diet group (P0.01 or 0.05), the degree of hepatic steatosis in the normal diet exercise group was not significantly different from that in the normal diet quiet group (P0.05), but the liver weight was higher than that in the normal diet quiet group (P0.01 or 0.05). Serum total cholesterol and triglyceride were significantly lower than those in normal diet quiet group (P0.01 or 0.05). Conclusion: high intensity intermittent training can effectively prevent NAFLD formed by high fat diet.
【作者单位】：河北师范大学体育学院;
【基金】：河北省自然科学基金资助(项目编号:C2013205151)
【分类号】：R87

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