21d模拟失重家兔股静脉血管反应性的变化

发布时间：2018-05-23 07:16

本文选题：失重模拟 + 股静脉　；参考：《航天医学与医学工程》2003年02期

【摘要】：目的研究模拟失重对下肢静脉系统的影响。方法将雄性新西兰家兔 2 4只 ,随机分为对照组、水平限动组和头低位限动组 ,每组 8只。利用离体血管环灌流技术 ,测量了 2 1d水平限动及 - 2 0°头低位限动家兔股静脉对组胺 (Ht)、苯肾上腺素 (PE)和氯化钾 (KCl)的收缩反应以及对乙酰胆碱 (ACh)和硝普钠(SNP)的舒张反应。结果 2 1d水平限动及头低位限动家兔股静脉对较高浓度PE和KCl的收缩反应均显著下降 (P 0 .0 5 ) ;对Ht的收缩反应有下降趋势 ,但无统计学意义 ;对ACh和SNP的舒张反应无显著变化。结论 2 1d模拟失重后家兔后肢深静脉对血管活性物质的收缩反应性下降 ,提示这可能是失重或模拟失重后立位耐力下降的原因之一
[Abstract]:Objective to study the effect of simulated weightlessness on venous system of lower extremity. Methods Twenty-four male New Zealand rabbits were randomly divided into control group (n = 8), horizontal restraint group (n = 8) and head-low motility group (n = 8). Using isolated vascular circulation perfusion technique, The contractile responses of rabbit femoral veins to histamine Httl, phenylephrine (PE) and potassium chloride (KCl) and relaxation to acetylcholine (ache) and sodium nitroprusside (SNPs) were measured. Results the contractile responses of femoral vein to higher concentrations of PE and KCl in rabbits were significantly decreased at 21 d (P < 0.05), but the contractile response to Ht was decreased, but there was no significant difference between the two groups in the contractile response of femoral vein to high concentration of PE and KCl. There was no significant change in diastolic response to ACh and SNP. Conclusion after 21 d simulated weightlessness, the contractile reactivity of deep vein of hind limb to vasoactive substances decreased in rabbits, which suggests that this may be one of the reasons for the decrease of orthostatic endurance after weightlessness or simulated weightlessness.
【作者单位】：航天医学工程研究所航天医学工程研究所航天医学工程研究所中科院上海生命科学院生命中心低氧实验室北京大学医学部航天医学工程研究所
【基金】：国家自然科学基金资助项目 (30 0 0 0 1197)
【分类号】：R85

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