胸部火器伤犬阻闭迷走神经对瞬时及早期心血管效应的影响

发布时间：2018-06-10 12:44

本文选题：胸部枪伤 + 心血管效应　；参考：《第四军医大学学报》2002年04期

【摘要】：目的　探讨阻闭迷走神经对犬胸部火器伤瞬时及早期心血管效应的影响 .方法　犬 1 2只随机平分为 2组 ,A组 :模型组 ,B组 :迷走神经封闭组 .各组分别用小口径步枪致伤 ,连续监测动脉压、静脉压、心率、肺动脉压、肺毛细血管嵌压、心电图 ,按时测心排血量 ,计算体循环血管阻力和肺血管阻力 .结果　两组犬枪伤瞬间血压均即刻呈单波峰升高 ,达伤前的 (1 .2± 0 .1 )倍 (P0 .0 5) ,而后缓慢下降 ;肺动脉压、肺嵌压亦出现相应变化 ,枪伤早期心排量减少 (1 .4± 0 .2 ) L·min-1 (P0 .0 1 ) ,每搏量减少 (9.0± 1 .1 ) L· beat-1 (P0 .0 1 ) ,同时体循环血管阻力增加 (64.9± 1 2 .1 ) k Pa· L-1 ·min-1 (P0 .0 1 )和肺血管阻力增加 (1 4 .9± 3.1 ) k Pa· L-1 ·min-1 (P0 .0 1 ) ,1 5 min左右达到顶点 ,而后逐渐恢复 .枪伤瞬间心率减慢 ,但很快恢复并逐渐加快 .B组犬枪伤瞬间上升单峰波仍然存在 ,但随后血压变化幅度较小 ,恢复亦较快 ,心率无瞬时下降 .心排量及血管阻力变化较 A组小 .结论　枪伤瞬时的心血管效应与迷走反射有关
[Abstract]:Objective to investigate the effect of vagus blocking on the transient and early cardiovascular effects of chest firearm injury in dogs. Methods Twelve dogs were randomly divided into 2 groups: group A: model group B: vagus nerve blocking group. The arterial pressure, venous pressure, heart rate, pulmonary artery pressure, pulmonary capillary pressure, electrocardiogram (ECG), cardiac output, systemic vascular resistance and pulmonary vascular resistance were measured in each group. Results in both groups, the blood pressure of the two groups increased at once with a single wave peak, reaching to 1. 2 卤0. 1 times before the injury (P0. 05), then decreased slowly, and the pulmonary artery pressure and pulmonary embedded pressure also showed corresponding changes. At the early stage of gunshot injury, cardiac output decreased by 1. 4 卤0. 2) L min-1 P0. 01), stroke volume decreased by 9. 0 卤1. 1) L beat-1 P0. 01). At the same time, the increase of systemic vascular resistance (64.9 卤1.2.1) KPA L-1 min-1 (P0. 01) and pulmonary vascular resistance (14.9 卤3.1) KPA L-1 min-1 P0. 01) reached its peak at about 15 min and gradually recovered. The heart rate slowed down at the moment of gunshot injury, but recovered quickly and gradually accelerated. The single peak wave in group B was still present, but the change of blood pressure was relatively small, the recovery was faster, and the heart rate did not drop instantaneously. The changes of cardiac output and vascular resistance were smaller in group A than in group A. Conclusion the transient cardiovascular effect of gunshot injury is related to vagal reflex.
【作者单位】：沈阳军区总医院心脏外科第四军医大学西京医院心血管外科中心第四军医大学西京医院心血管外科中心第四军医大学西京医院心血管外科中心第四军医大学西京医院心血管外科中心第四军医大学西京医院心血管外科中心第四军医大学西京医院心血管外科中心
【基金】：全军“九五”指令性课题 ( 96 L0 4 6 )
【分类号】：R826.65

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