4周封闭式运动减肥夏令营对肥胖青少年血清SFRP5、TLR4的影响研究

发布时间：2018-02-17 07:34

本文关键词： 封闭式运动减肥肥胖青少年 SFRP5 TLR4胰岛素抵抗　出处：《武汉体育学院》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过对运动减肥夏令营内的肥胖青少年进行4周的追踪和数据采集分析,探讨分析肥胖青少年减肥前后的身体体成分变化,以及对血液炎性因子IL-6、TNF-α、抗炎因子SFRP5、促炎因子TLR4的影响及作用。摸清各指标变化的原因和机制,从生理学角度对运动减肥提供理论依据,从而达到科学减肥的目的。方法:本研究以25名参加封闭式减肥夏令营的12-18岁肥胖青少年为实验组,13名12-18岁健康青少年为对照组。入营时各组测量身高、体重、体成份、IL-6、TNF-α、SFRP5、TLR4等指标,通过4周封闭式减肥训练后,研究实验组青少年身体形态、及血液中IL-6、TNF-α、SFRP5、TLR4等指标的变化。结果:(1)4周运动减肥后,实验组青少年的体重、去脂体重、身体脂肪量、体脂率、BMI、躯干及左右上下肢脂肪量均比减肥前呈显著性下降(P0.01)。其中,肥胖组体重平均下降了10.32%,去脂体重下降了4.87%,身体脂肪量下降了19.96%,体脂百分比下降了11.70%,BMI下降了10.81%,躯干及左右上下肢脂肪量分别下降了19.87%、19.52%、20.00%、20.10%、20.06%。(2)4周运动减肥前,实验组青少年IL-6、TNF-α、CRP、FINS、HOMA-IR显著高于对照组(P0.05),SFRP5显著性低于对照组(p0.05);TLR4高于对照组但无统计学差异(P0.05)。(3)4周运动减肥后,实验组青少年SFRP5显著升高(p0.05);IL-6、TNF-α有显著性下降(p0.05);TLR4虽无显著性差异,但有下降的趋势(P0.05)。CRP、FINS、HOME-IR显著性下降(p0.05)。结论:(1)通过4周运动减肥可使肥胖青少年的体成分得到明显改善,并使身体脂含量明显降低,达到减肥塑身效果。(2)减肥前肥胖青少年已存在慢性炎症状态,经过4周运动减肥后血液中的炎性因子IL-6、TNF-α显著减少,TLR4有下降的趋势,抗炎因子SFRP5明显增加,说明通过封闭式运动减肥可改善炎症状态,这对促进人体健康,增强人体免疫力有着重要意义。(3)4周运动减肥对于改善胰岛素抵抗,调节糖代谢有着重要作用。
[Abstract]:Objective: to investigate the changes of body composition of obese adolescents before and after losing weight by following up and collecting data for 4 weeks in sports and weight loss summer camp. The effects of IL-6 TNF- 伪, anti-inflammatory factor SFRP5, and pro-inflammatory factor TLR4 on the changes of blood inflammatory factor IL-6 TNF- 伪, anti-inflammatory factor SFRP5 and proinflammatory factor TLR4 were also studied. The causes and mechanisms of the changes were investigated, and the theoretical basis for exercise weight loss was provided from the physiological point of view. In order to achieve the objective of scientific weight loss. Methods: 25 obese adolescents aged 12-18 years participating in closed weight loss summer camp were used as experimental group and 13 healthy adolescents aged 12-18 years as control group. The height and weight of each group were measured at the time of entering the camp. After 4 weeks of closed weight loss training, the changes of body shape and blood IL-6 TNF- 伪 of SFRP5 TLR4 in experimental group were studied. Results after 4 weeks of exercise, the body weight, fat loss and body fat content of the experimental group were measured. The body fat rate and the fat content of trunk and left upper and lower extremities were significantly lower than those before weight loss (P 0.01). The obese group lost an average of 10.32 points in body weight, 4.87 in degreasing weight, 19.96 in body fat, 11.70 in body fat, and 10.81 in BMI, and 19.87 in the trunk and in the upper and lower limbs, 19.87 in the upper and lower extremities, 20.100 in the upper and lower extremities, and 20.10 in the 20. 06. 22 weeks before you lost weight. Compared with the control group, the levels of IL-6 TNF- 伪 CRPN- FINS- 伪 HOMA-IR were significantly lower than that of the control group (P 0.05), but there was no significant difference between the control group and the control group. After 4 weeks of exercise, the SFRP5 of the adolescents in the experimental group significantly increased the level of IL-6TNF- 伪, although there was no significant difference between the two groups, although there was no significant difference in the level of TLR4, there was no significant difference between the adolescents in the experimental group and the control group in the level of IL-6TNF- 伪, although there was no significant difference in the level of TLR4, although there was no significant difference between the two groups after 4 weeks of exercise. But there is a tendency to decrease the body composition of obese adolescents, and the body fat content of obese adolescents can be significantly decreased by 4 weeks exercise. Conclusion: the body composition of obese adolescents can be significantly improved and the body fat content can be significantly decreased by 4 weeks of exercise to reduce the body mass fraction of obese adolescents, and to reduce the body fat content of obese adolescents, and to reduce the body fat content of the obese adolescents, and to reduce the body fat content of obese adolescents. After 4 weeks exercise, the inflammatory factor (IL-6) TNF- 伪 decreased significantly, and the anti-inflammatory factor (SFRP5) increased significantly. It is suggested that the closed exercise can improve the inflammatory state, which is of great significance to the promotion of human health and the enhancement of human immunity. 4 weeks exercise can improve insulin resistance and regulate glucose metabolism.
【学位授予单位】：武汉体育学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：G804.2

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