耐力运动对大鼠心肌GR和MR表达的影响

发布时间：2018-06-05 17:53

本文选题：运动 + 心肌　；参考：《首都体育学院学报》2017年04期

【摘要】：研究不同训练状态大鼠心肌糖皮质激素受体(GR)和盐皮质激素受体(MR)的表达规律,探讨其在运动心肌适应过程中可能产生的作用。方法:大鼠分别采用一次耐力运动、4周和10周的递增负荷耐力运动训练方案,并在末次运动后0 h、3 h、24 h取材,采用Western blot方法测定左室心肌相应的指标。结果:肾上腺重量以及肾上腺/体重在4周和10周的训练大鼠均显著增加;而心肌GR和MR的表达在4周递增负荷耐力训练后与安静对照组比较显著下降,经过10周递增负荷耐力训练后,受体表达量与安静对照组无明显差异。一次、4周和10周的耐力运动对大鼠心肌p-SGK1/SGK1没有明显影响;但心肌HSP70的表达量随着运动训练的持续,呈递增性提高。结论:大鼠心肌GR和MR表达以及受体与配体的亲和力与运动训练状态有关,这些变化可能参与了运动心肌的适应过程。
[Abstract]:To study the expression of glucocorticoid receptor (GRG) and salt corticosteroid receptor (MRR) in rat myocardium under different training conditions and to explore its possible role in the process of exercise myocardial adaptation. Methods: the rats were trained with one endurance exercise for 4 weeks and 10 weeks respectively. The left ventricular myocardial indexes were measured by Western blot method at 0 h, 3 h and 24 h after the last exercise. Results: the weight of adrenal gland and adrenal / body weight increased significantly at 4 and 10 weeks, while the expression of gr and Mr decreased significantly after 4 weeks of incremental stress endurance training. After 10 weeks of incremental load endurance training, there was no significant difference in the expression of receptor between the control group and the quiet control group. Endurance exercise for 4 and 10 weeks had no significant effect on myocardial p-SGK1/SGK1 in rats, but the expression of myocardial HSP70 increased progressively with the continuous exercise training. Conclusion: the expression of gr and Mr and the affinity between receptor and ligand are related to the state of exercise training. These changes may be involved in the adaptation of exercise myocardium.
【作者单位】：首都体育学院;
【基金】：北京市教委科技面上项目(KM201310029001);北京市教委学科建设项目(PXM2015_014206_000040,PXM2015_014206_000072)
【分类号】：G804.2

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