错配修复基因与大肠癌相关性研究进展

发布时间：2018-01-02 01:00

本文关键词：错配修复基因与大肠癌相关性研究进展　出处：《中华肿瘤防治杂志》2016年23期 　论文类型：期刊论文

【摘要】：目的 MMR系统是一组高度保守基因及其产物蛋白构成,其主要功能是纠正DNA复制、重组及基因损伤时出现的碱基配对错误。本研究总结国内外错配修复基因与大肠癌相关性的研究进展。方法检索Pubmed和万方数据库,以"错配修复基因、微卫星不稳定、大肠癌"等为关键词,检索1997-01-2016-06的相关文献共102篇。纳入标准:(1)错配修复基因与微卫星不稳定的关系。(2)错配修复基因大肠癌的发生及预后的关系。根据纳入标准,最终选取49篇文献纳入分析。结果错配修复系统是一种广泛存在于机体细胞内的自我修复机制,对防止基因突变和维持基因组稳定性方面起着重要作用。错配修复基因突变与微卫星不稳定关系密切,错配修复基因发生突变时,使机体肿瘤易感性明显增加。结论错配修复系统是大肠癌的发生、发展的重要预后指标。
[Abstract]:MMR system is a group of highly conserved gene and its protein product, its main function is to correct the emergence of DNA replication, recombination and gene damage the base pairing error. Research progress of this study summarized the correlation between mismatch repair gene and colorectal carcinoma. Methods we searched the Pubmed and Wanfang database, the mismatch repair gene, microsatellite instability, colorectal cancer "as key words, literature retrieval 1997-01-2016-06 a total of 102. Inclusion criteria: (1) the relationship between mismatch repair gene and microsatellite instability. (2) the relationship between the occurrence and prognosis of mismatch repair genes in colorectal cancer. According to the inclusion criteria, the final selection of 49 included in this analysis. Results the mismatch repair system is a self repair mechanism widely exists in the cells of the body, it plays an important role in preventing gene mutation and maintenance of genome stability and gene mutation of mismatch repair. Microsatellite instability is closely related. When the mismatch repair gene mutated, the susceptibility of the tumor increased significantly. Conclusion the mismatch repair system is an important prognostic indicator for the occurrence and development of colorectal cancer.

【作者单位】：威海市立医院胃肠外科;山东省省立医院胃肠外科;
【分类号】：R735.34
【正文快照】： 2.山东省省立医院胃肠外科,山东济南250021中华肿瘤防治杂志,2016,23(23):1592-1596Chin J Cancer Prev Treat,2016,23(23):1592-1596大肠癌是常见的恶性肿瘤之一,根据WHO 2014年“世界癌症报告”,大肠癌发病率居所有癌症的第3位,2012年新病例达136.1万,占所有癌症的9.7%;死亡

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