探讨GABAARG2基因在癫痫耐药机制中的作用

发布时间：2018-02-14 04:50

本文关键词： GABAARG基因苯妥英耐药性癫痫多形性　出处：《中风与神经疾病杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨癫痫患者中GABAARG2基因与耐药性癫痫的关系。方法选择来本院就诊的98例癫痫患者,根据对抗癫痫药物的反应性分为耐药组(观察组)46例和敏感组(对照组)52例进行研究,提取所有患者的DNA,采用PCR基因测序鉴定GABAARG2基因出现的概率,对每一位受试者以口服传统的抗癫痫药物-苯妥英(phenytoin)方式来对比两组患者的药物口服吸收率。结果观察组和对照组之间的年龄、性别、既往病史、持续状态方面差异均无统计学意义(P0.05)。观察组出现GABAARG2基因的概率显着高于对照组,差异具有统计学意义(χ~2=8.08,P=0.01);观察组的总体口服吸收率(68.71%±12.28%)明显低于对照组的口服吸收率(82.36%±15.31%),差异具有统计学意义(χ~2=6.78,P=0.01)。结论 GABAARG2基因的在脑内的出现会影响抗癫痫药物的效果,进而引起患者的耐药性,对临床治疗有较好的参考价值。
[Abstract]:Objective to investigate the relationship between GABAARG2 gene and drug resistance in patients with epilepsy epilepsy. Methods 98 cases of patients with epilepsy in our hospital, according to the reaction of anti epileptic drugs divided into resistant group (observation group) 46 cases and sensitive group (control group) 52 cases were studied. The extraction of DNA of all patients, the probability of PCR gene sequencing GABAARG2 gene, each of the subjects with oral traditional antiepileptic drugs phenytoin (phenytoin) to oral drug absorption rate were compared between two groups. Results between the observation group and control group in age, gender, medical history, persistent differences had no statistical significance (P0.05). The observation group probability of GABAARG2 gene was significantly higher than the control group, the difference was statistically significant (~2=8.08, P=0.01); the observation group's overall oral absorption rate (68.71% + 12.28%) was significantly lower than the control group oral absorption rate (82.3 6% + 15.31%), the difference was statistically significant (x ~2=6.78, P=0.01). Conclusion the presence of GABAARG2 gene in the brain will affect the effect of antiepileptic drugs, and then lead to drug resistance, so it has a good reference value for clinical treatment.

【作者单位】：云南省第三人民医院神经内科;
【分类号】：R742.1

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