晚期大肠癌患者中医证素与KRAS、BRAF、NRAS基因突变情况的相关性研究

发布时间：2018-02-16 00:06

本文关键词： 大肠癌中医证素肿瘤基因突变　出处：《中国中西医结合杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的研究晚期大肠癌患者KRAS、BRAF、NRAS基因突变情况与中医证素的相关性。方法收集33例晚期大肠癌患者中医证素和KRAS、BRAF、NRAS基因情况(突变"+"或野生非突变"-")。采用二分类Logistic回归分析基因突变情况与证素的相关性。结果 KRAS野生型与肝郁呈负相关(P=0.043,P0.05),KRAS突变型与肝郁呈正相关(P=0.043,P0.05)。KRAS野生型、KRAS突变型均与脾虚、肺虚、肾虚、阳虚、阴虚、气虚、血虚、痰浊、气滞、血瘀相关性不显著(P0.05)。BRAF野生型、NRAS野生型均与肝郁、脾虚、肺虚、肾虚、阳虚、阴虚、气虚、血虚、痰浊、气滞、血瘀逻辑相关性不显著(P0.05)。BRAF突变型、NRAS突变型检测阳性者少,未纳入统计分析。结论晚期大肠癌患者KRAS基因突变情况与肝郁存在相关性。KRAS野生型与肝郁呈显著负相关,KRAS突变型与肝郁呈正相关,BRAF、NRAS突变与否与中医证素无直接相关性。
[Abstract]:Objective to study the relationship between the mutation of KRASA BRAFU NRAS gene and TCM syndromes in patients with advanced colorectal cancer. Methods 33 patients with advanced colorectal cancer were collected the status of TCM syndromes and KRAS-BRAFRAFRAS gene (mutation "or wild non-mutation" -). Results there was a negative correlation between KRAS wild type and liver depression. There was a positive correlation between KRAS wild type and liver depression. Lung deficiency, kidney deficiency, yang deficiency, yin deficiency, qi deficiency, blood deficiency, phlegm turbidity, Qi stagnation and blood stasis were not significantly correlated with liver depression, spleen deficiency, lung deficiency, kidney deficiency, yang deficiency, yin deficiency, qi deficiency, blood deficiency, phlegm turbidity, qi stagnation, and liver depression, spleen deficiency, lung deficiency, kidney deficiency, yang deficiency, yin deficiency, qi deficiency, blood deficiency, phlegm turbidity, qi stagnation, There was no significant correlation between blood stasis logic and blood stasis. There were few patients with positive NRAS mutation of BRAF mutation. Conclusion there is a significant negative correlation between KRAS gene mutation and liver depression in patients with advanced colorectal cancer. There is a significant negative correlation between KRAS wild type and liver depression. There is no direct correlation between KRAS mutation and liver depression.
【作者单位】：中国中医科学院西苑医院肿瘤科;四川省肿瘤医院中西医结合科;
【基金】：中国中医科学院基本科研业务费自主选题资助项目(No.ZZ070854) 北京市科技计划项目(No.Z131107002213101)
【分类号】：R273

【相似文献】