G蛋白β3基因C825T多态性作为抑郁症危险因素的Meta分析

发布时间：2018-03-06 23:21

本文选题：抑郁症　切入点：GNβ3　出处：《重庆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：背景:有研究发现G蛋白β3基因(GNβ3)通过影响几种神经递质受体的胞内转导而与精神疾病相关。一些研究探讨了GNβ3基因的C825T多态性(GNβ3C825T)与抑郁和抗抑郁治疗反应的关系,然而就目前的研究而言,GNβ3C825T与抑郁症之间的关系仍然不一致。因此,我们试图通过Meta分析发现GNβ3C825T作为抑郁症危险因素对抑郁症易感性的影响。方法:根据PRISMA声明(系统综述和荟萃分析优先报告的条目)的要求开展本次Meta分析。我们系统检索了1990年1月至2014年9月期间Pub Med,Scopus,Science Direct,Springer,Embase,psy INFO和CNKI收录的所有已发表的GNβ3C825T与抑郁症关联的研究。通过比值比(OR)及其95%置信区间(CI)评估GNβ3C825T与抑郁风险之间的关联。计算了等位基因比较(C与T),纯合子(CC与TT)模型,杂合子(CC与CT)模型,显性模型(CC+CT与TT)和隐性模型(CC与TT+CT)的OR合并值,另外根据种族进行了亚组分析。为了评估各模型的潜在偏倚,通过留一法研究来进行灵敏度分析来评估每个研究对合并值的影响。结果:共筛选出9个病例对照研究,包含1055例抑郁症患者和1325例健康对照者。分析发现等位基因模型下GNβ3 C825T的T等位基因OR合并值与抑郁风险显著相关,同时在显性模型、隐性模型、杂合子模型下也观察到GNβ3C825T的T等位基因与抑郁风险之间的显著关联。GNβ3C825T的T等位基因可增加抑郁症的易感性。种族亚组分析发现亚洲种群存在该关联,而高加索人中没有发现该关联。结论:本研究为揭示GNβ3C825T与抑郁症关系的第一个Meta分析。我们发现亚洲人中GNβ3C825T的T等位基因携带者更容易患抑郁症。相比之下,高加索人中GNβ3C825T的T等位基因携带者和抑郁风险之间没有显著的相关性。这些结果可能会为临床医生和公共卫生管理人员提供评估抑郁症的重要筛查工具。
[Abstract]:Background: it has been found that G protein 尾 3 gene (GN 尾 3) is associated with mental illness by affecting intracellular transduction of several neurotransmitter receptors. Some studies have explored the relationship between the C825T polymorphism of GN 尾 3 gene and depression and antidepressant response. However, the relationship between GN 尾 3C825T and depression is still inconsistent in current studies. We try to find out the influence of GN 尾 3C825T as a risk factor of depression on the susceptibility of depression through Meta analysis. Methods: to carry out this Meta analysis according to the requirements of the PRISMA statement (the items of systematic review and meta-analysis priority report). We systematically searched all published studies on the association of GN 尾 3C825T with depression recorded by Pub Medus Scopus Science Direct Spring INFO and CNKI between January 1990 and September 2014. The association between GN 尾 3C825T and depression risk was assessed by ratio ratio ratio and its 95% confidence interval. The allelic comparison models of C and TX, homozygote CC and TTT were calculated. In order to evaluate the potential bias of each model, the combined OR values of CC and CTS models, dominant model CCCT and TTT) and recessive model of CC and TT CTs were analyzed by subgroup analysis according to race, in order to evaluate the potential bias of each model. A sensitivity analysis was conducted to assess the impact of each study on the combined value. Results: nine case-control studies were selected. There were 1055 patients with depression and 1325 healthy controls. The results showed that the combination of T allele OR of GN 尾 3C825T was significantly correlated with the risk of depression in the dominant model and recessive model. A significant association between the T allele of GN 尾 3C825T and the risk of depression was also observed under heterozygote model. The T allele of GN 尾 3C825T increased the susceptibility to depression. Conclusion: this study was the first Meta analysis to reveal the relationship between GN 尾 3C825T and depression. We found that the T allele carriers of GN 尾 3C825T were more likely to develop depression in Asian population. There was no significant correlation between T allele carriers of GN 尾 3C825T and risk of depression in Caucasians. These results may provide clinicians and public health administrators with an important screening tool for assessing depression.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749.4

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