ADAM33基因rs2280090、rs487377、rs2787094多态性与大鱼际掌纹特应征的相关性研究

发布时间：2018-03-15 04:20

  本文选题：哮喘　切入点：大鱼际掌纹特应征　出处：《中华中医药学刊》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨ADAM33基因多态性与青岛地区汉族成人哮喘患者大鱼际掌纹特应征的相关性。方法:引入计算机识别系统,实现大鱼际掌纹特应征客观量化分级,采用SNa Pshot方法检测400例哮喘患者和200例正常对照的ADAM33基因rs2280090、rs487377、rs2787094共3个多态位点的基因型和等位基因频率。结果:相对于CC-CG基因型,rs2787094的GG基因型频率在掌纹阴性组为11.3%,在掌纹阳性组为18.9%,差异有统计学意义(OR=2.10,95%=1.26-3.50,P=0.003 8)。结论:ADAM33基因rs2787094多态性与哮喘患者的大鱼际掌纹特应征呈显著相关,而rs2280090、rs487377多态性和掌纹无相关性。
[Abstract]:Objective: to investigate the association between ADAM33 gene polymorphism and the application of palmar palmprint in adult asthmatic patients in Qingdao. Methods: a computer recognition system was introduced to realize the objective and quantitative classification of the application of the hypothenar palmprint. The genotypes and alleles of three polymorphic loci of ADAM33 gene rs487377rs2787094 were detected by SNa Pshot method in 400 asthmatic patients and 200 normal controls. Results: the GG genotype frequency of rs2787094 was higher than that of CC-CG genotype in palmprint negative group. 11.3in the palmprint positive group, it was 18.9, and the difference was statistically significant. Conclusion the rs2787094 polymorphism of the 20% ADAM33 gene is significantly associated with the specific application of hypothenar palmprint in asthmatic patients. There was no correlation between rs2280090 rs487377 polymorphism and palmprint.
【作者单位】： 青岛市中医医院肺病科;青岛科技大学信息科学技术学院;
【分类号】：R2-03
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本文编号：1614408