MAOA基因T941G多态性与同伴侵害对男青少年早期抑郁的交互作用:COMT基因Val158Met多态性的调节效应

发布时间：2018-03-23 12:25

本文选题：MAOA基因　切入点：COMT基因　出处：《心理学报》2017年02期

【摘要】：抑郁具有复杂的多基因遗传基础,然而既有研究大多采用单基因以及单基因-环境交互设计(G×E)考察抑郁的遗传机制。以757名男青少年为被试(初次测评时Mage=11.32岁,SD=0.49岁),采用多基因-环境交互(G×G×E)设计,本研究考察了MAOA(monoamine oxidase A,单胺氧化酶A)基因T941G多态性、COMT(catechol-O-methyltransferase,儿茶酚胺氧位甲基转移酶)基因Val158Met多态性与同伴侵害对青少年早期抑郁的影响。结果显示,MAOA基因T941G多态性与同伴侵害交互作用于青少年抑郁,同伴侵害仅显著正向预测G等位基因(而非T等位基因)青少年抑郁。而且,MAOA基因T941G多态性与同伴侵害的交互作用受到COMT基因Val158Met多态性的调节,上述交互作用仅存在于COMT Met等位基因而非Val/Val基因型携带者中。研究结果显示,抑郁的产生与个体差异存在多基因与环境间的复杂交互机制。
[Abstract]:Depression has a complex genetic basis for polygenes, However, most of the existing studies used single gene and single gene-environment interaction design (GXE) to investigate the genetic mechanism of depression. 757 male adolescents were selected as subjects (Mage=11.32 0. 49 years old, polygene-environment interaction G 脳 G 脳 E) design. The effect of Val158Met polymorphism of MAOA(monoamine oxidase A (monoamine oxidase A) gene T941G polymorphism of COMTcatechol-O-methyltransferase (catechol-O-methyltransferase) gene and peer invasion on early depression in adolescents was investigated. Companion aggression interacts with depression in adolescents, Peer aggression only positively predicted depression in adolescents with G allele (not T allele), and the interaction between MAOA gene T941G polymorphism and peer aggression was regulated by COMT gene Val158Met polymorphism. These interactions were found only in COMT Met alleles and not in Val/Val genotype carriers. The results showed that there was a complex interaction mechanism between multiple genes and environment in the generation of depression and individual differences.
【作者单位】：山东师范大学心理学院;
【基金】：国家自然科学基金项目(31271105);国家自然科学基金项目(31671156) 高等学校博士学科点专项科研基金项目(20133704110001) “十二五”强化建设重点学科(发展与教育心理学)建设经费资助项目
【分类号】：R749.4

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