肺浸润性腺癌EGFR基因突变状态与影像学特征及病理亚型的相关性研究

发布时间：2018-04-11 17:01

本文选题：肺浸润性腺癌 + 表皮生长因子受体　；参考：《福建医科大学》2016年硕士论文

【摘要】：目的:探讨肺浸润性腺癌患者表皮生长因子受体(EGFR)基因的突变状态与影像学特征、病理亚型等之间的相关性。方法:本文回顾性分析2013年6月到2014年12月之间收治的84例肺浸润性腺癌病例的临床资料,所收集的病例均为我院病理确诊为肺浸润性腺癌,并进一步行EGFR基因突变状态的检测,分析肺浸润性腺癌患者EGFR基因突变状态和突变位点与影像学特征、病理亚型等之间的相关性。结果:总体的EGFR基因突变率为70.2%,女性突变率为82.8%,男性突变率为61.2%,两者之间的差异具有统计学意义(P0.05);CT影像上表现为肺结节内含磨玻璃影(GGO)成分者突变率为82.8%,CT影像上表现为全实性肺结节者突变率为59.4%,两者差异具有统计学意义(P0.05);病理亚型之间:腺泡为主型组突变率为71.7%;贴壁为主型组突变率为83.3%;乳头为主型组突变率为60.0%;微乳头为主型突变率100%;实性为主型组的突变率为50.0%,各组之间突变率无明显差别(P0.05);EGFR基因突变位点与患者性别或影像学上是否含GGO成分无明显相关性,EGFR基因突变位点在病理分型为贴壁为主型组和腺泡为主型组之间无明显差异。结论:肺浸润性腺癌中,EGFR基因在女性、影像学上提示含GGO成分者突变率高,而EGFR基因突变与病理亚型之间无明确关系;EGFR基因的突变位点与性别、影像上是否含GGO成分无明显相关性,EGFR基因突变位点在病理分型为贴壁为主型组和腺泡为主型组之间无明显差异。
[Abstract]:Objective: to investigate the relationship between epidermal growth factor receptor (EGFR) gene mutation and imaging features and pathological subtypes in patients with invasive lung adenocarcinoma.Methods: the clinical data of 84 cases of pulmonary infiltrating adenocarcinoma between June 2013 and December 2014 were retrospectively analyzed.The mutation status and mutation site of EGFR gene in patients with lung infiltrating adenocarcinomas were analyzed by detecting the mutation status of EGFR gene, and the correlation between the mutation status of EGFR gene and the imaging features and pathological subtypes were analyzed.Results: the total mutation rate of EGFR gene was 70.2%, female mutation rate was 82.8%, male mutation rate was 61.2%. The difference between them was statistically significant (P 0.05%).The mutation rate was 59.4 in the patients with total solid pulmonary nodules, and the difference was statistically significant (P 0.05); among the pathological subtypes, the mutation rate of the acinar predominant type was 71.7; the adherent type was 83.3%; the nipple dominant type was 60.05; the micropapilla was the micronipple.There was no significant difference between the mutation rate of GGO gene and the sex or imaging of the patients. There was no significant correlation between the mutation rate of EGFR gene and the sex or imaging of the patients.There was no significant difference between adherent type and acinar type.Conclusion: in female patients with invasive lung adenocarcinoma, the mutation rate of GGO gene is high on imaging, but there is no clear relationship between EGFR gene mutation and pathological subtype.There was no significant correlation between the GGO gene mutation and the pathological classification between the adherent type group and the acinar type group, and there was no significant difference between the pathological type and the acinar type group.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R734.2

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