IL12RB1和IL12RB2基因多态性与中国汉族儿童结核病易感的关联研究

发布时间：2018-04-14 10:24

本文选题：结核病 + ILRB　；参考：《中国实用儿科杂志》2017年09期

【摘要】：目的探讨IL12RB1和IL12RB2基因多态性与中国汉族儿童结核病(TB)易感的相关性。方法收集2005年2月至2011年10月首都医科大学附属北京儿童医院收治的362例汉族儿童TB患者的临床资料,以同期进行体检的未患TB的400名儿童作为对照,开展病例对照研究。利用高通量的Mass ARRAY平台,对于IL12RB1和IL12RB2基因的16个单核苷酸多态性(single nucleotide polymorphisms,SNP)位点展开基因分型。通过Logistic回归分析两组间各SNP位点等位基因频率和基因型频率的分布差异,并应用多因子降维法(multifactor dimensionality reduction,MDR)分析两组间各基因SNP位点间交互作用与TB易感的相关性。结果 IL12RB1和IL12RB2基因各SNP位点的等位基因、基因型以及单体型的组间频率分布差异均无统计学意义(P0.0036)。MDR方法分析结果未发现各基因SNP间交互作用与TB易感的相关性(P0.0036)。结论 IL12RB1和IL12RB2基因多态性可能与中国汉族儿童TB的发病并无相关性。
[Abstract]:Objective to investigate the association of IL12RB1 and IL12RB2 gene polymorphisms with susceptibility to tuberculosis in Chinese Han children.Methods Clinical data of 362 children with TB from Beijing Children's Hospital affiliated to Capital Medical University from February 2005 to October 2011 were collected. 400 children who were not suffering from TB in the same period of physical examination were used as control group to carry out a case-control study.Using a high-throughput Mass ARRAY platform, 16 single nucleotide polymorphisms of IL12RB1 and IL12RB2 genes were genotyped.The distribution of allele frequency and genotype frequency of SNP locus between the two groups were analyzed by Logistic regression analysis. The correlation between the interaction of SNP loci and the susceptibility to TB was analyzed by multifactor dimensionality reduction.Results there was no significant difference in alleles, genotypes and haplotypes between alleles, genotypes and haplotypes of SNP loci of IL12RB1 and IL12RB2 genes.Conclusion IL12RB1 and IL12RB2 gene polymorphisms may not be associated with TB in Chinese Han children.
【作者单位】：国家儿童医学中心首都医科大学附属北京儿童医院国家呼吸系统疾病临床医学研究中心呼吸科儿科学国家重点学科儿科重大疾病研究教育部重点实验室儿童呼吸道感染性疾病研究北京市重点实验室;国家儿童医学中心首都医科大学附属北京儿童医院国家呼吸系统疾病临床医学研究中心北京市儿科研究所儿科学国家重点学科儿科重大疾病研究教育部重点实验室儿童呼吸道感染性疾病研究北京市重点实验室;
【分类号】：R529.9

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