COMT基因、父母教养方式与创造力的关系

发布时间：2018-05-20 00:26

本文选题：创造力 + COMT基因　；参考：《山东师范大学》2017年硕士论文

【摘要】：创造力是社会发展的动力,也是个体取得成功必须具备的能力。个体创造力受到遗传和环境的共同作用,而且随着分子遗传学的发展,人们开始关注与创造力有关的基因及其与环境的交互作用。COMT基因是创造力重要的候选基因,父母教养方式是影响创造力的重要环境变量,二者交互作用可能对创造力有重要影响。此外,之前研究中单位点与环境交互作用的效果量普遍较小,而且对多位点联合作用的忽视可能会限制研究者对个体生物易感性范围的考察。由于某些基因效应上潜在的性别差异,将涉及这些基因的分析分性别考察可能更合适。鉴于此,本研究拟考察COMT基因(多位点联合作用)与父母教养方式的交互作用对创造力的影响及其性别差异。本研究的被试采用427名中国健康汉族的大学生,采用候选基因研究策略,对COMT基因上12个多态性位点进行考察。首先采集被试静脉血然后进行DNA提取和基因分型,之后使用问卷调查法对个体的创造力及父母教养方式进行测量。首先通过COMT基因单位点与父母教养方式交互作用的分析,发现与创造力有关的易感等位基因,之后以累加的方式(Pearson et al.,2014)计算出个体COMT基因多位点联合的遗传易感性指数(cumulative genetic susceptibility index,CGSI),从而考察CGSI与父母教养的交互作用对创造力水平差异的影响以及性别在其中可能的调节作用。本研究结论如下:(1)COMT基因(多位点联合)与父母教养方式对创造力的交互作用显著。表现为携带更多的易感等位基因的个体(CGSI1=3,CGSI2=4,5,CGSI3=2)在受到积极教养(高父/母权威或低母亲放任)的影响时创造力水平更高,在受到消极教养(低父/母权威或高母亲放任)的影响时创造力水平更低。(2)COMT基因与父母教养方式对创造力的交互作用具有性别差异。对女性而言,rs5993882、rs4646312、rs6269、rs4818、rs769224和母亲权威型教养方式共同影响创造力(流畅性和独创性)。对男性而言,rs6269、rs4818和父亲权威型教养及母亲放任型教养方式共同影响创造力(独创性和灵活性)。(3)COMT基因与父母教养方式的交互作用的模式在不同位点上不同。CGSI(rs5993882、rs4646312和rs6269)与CGSI2(rs5993882、rs4646312、rs6269、rs4818和rs769224)同母亲权威对女性创造力独创性的交互作用符合不同易感模型;CGSI3(rs6269和rs4818)与母亲放任对男性创造力独创性的交互作用符合不同易感模型;CGSI3(rs6269和rs4818)与父亲权威对男性创造力独创性的交互作用符合素质-压力模型;CGSI3(rs6269和rs4818)与母亲放任对男性创造力灵活性的交互作用符合优势敏感模型。
[Abstract]:Creativity is the driving force of social development and the ability of individuals to succeed. Individual creativity is influenced by heredity and environment, and with the development of molecular genetics, people begin to pay attention to the genes related to creativity and their interaction with environment. COMT gene is an important candidate gene for creativity. Parental rearing style is an important environmental variable affecting creativity, and the interaction between them may have an important impact on creativity. In addition, the effect of the interaction between unit point and environment in previous studies is generally small, and the neglect of the combination of multiple sites may limit the study of the range of individual biological susceptibility. Because of the potential gender differences in the effects of some genes, it may be more appropriate to examine the sex of the genes involved in the analysis. In view of this, this study intends to investigate the interaction between COMT gene and parental rearing style on creativity and its gender differences. Twelve polymorphic loci of COMT gene were studied in 427 healthy Chinese college students using candidate gene research strategy. First, the venous blood was collected, then DNA was extracted and genotyped, and then the creativity and parental rearing style were measured by questionnaire. First, by analyzing the interaction between COMT gene unit and parental rearing style, we found the susceptible alleles related to creativity. Then the cumulative method of Pearson et al.n2014) was used to calculate the genetic susceptibility index of individuals with multiple loci of COMT gene and the cumulative genetic susceptibility index, so as to investigate the influence of the interaction between CGSI and parental upbringing on the difference of creativity level and the possible regulation of gender among them. The results showed that the interaction of COMT gene (multiple loci combination) and parental rearing style on creativity was significant. Individuals with more susceptible alleles were found to have higher levels of creativity under the influence of active upbringing (high parent authority or low maternal indulgence). Under the influence of negative parenting (low parental authority or high maternal laissez-faire), the creativity level was lower. The interaction between COMT gene and parental rearing style had gender differences. For women, rs5993882 / rs4646312 / rs6269 / rs4818 / rs769224 and mother's authoritative upbringing influence creativity (fluency and originality). For men, rs6269rs4818 and father's authoritative parenting and mother's laissez-faire parenting patterns affect creativity (the patterns of interaction between the original and flexible COMT gene and parental rearing styles vary at different loci.) and CGSI2rs5993882 rs4646312 and rs6269) and CGSI2rs5993882rs463269rs4818 The interaction with mother authority on female creativity originality in accordance with different susceptibility models: CGSI3rs6269 and rs4818) and mother's laissez-faire interaction on male creativity originality in accordance with different susceptibility models CGSI3rs6269 and rs4818) and paternal authority on men The interaction of creativity originality was consistent with the quality-stress model CGSI3Rs6269 and rs4818) and the interaction of mother's laissez-faire to male creativity flexibility was in accordance with the advantage sensitive model.
【学位授予单位】：山东师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：B844.2;G78

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