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转录因子7类似物-2基因rs12255372多态性与妊娠期糖尿病发病风险的系统评价

发布时间:2018-10-15 14:48
【摘要】:目的探讨转录因子7类似物-2(TCF7L2)基因rs12255372 GT多态性与妊娠期糖尿病(GDM)发病风险的关系。方法截止2016年9月,检索NCBI Pub Med、中国知网(CNKI)及万方等数据库关于rs12255372多态性与GDM发病相关病例-对照研究。Stata12.0软件检测所纳入数据发表偏倚及异质性,以合并效应的OR及95%置信区间(95%CI)评估rs12255372位点与GDM的发病风险。结果依据纳入、排除标准,共9篇文献,包含5778例研究对象纳入本研究。Meta分析显示,与G基因型相比,T等位基因携带者GDM发病风险显著增高,整体合并效应的OR值及95%CI为1.28(1.16~1.40);以种族进行亚组分析,高加索人群合并效应的OR及95%CI为1.29(1.15~1.45),亚洲人群为1.25(1.05~1.48)。基因型分析显示,显性遗传模型下,rs12255372 GT与GDM发病显著相关,与GG基因型相比,GT+TT基因型携带者GDM发病风险显著增高,整体合并效应的OR及95%CI为1.35(1.20~1.53),高加索人群为1.39(1.20~1.62),亚洲人群为1.28(1.04~1.58)。结论 TCF7L2rs12255372 GT多态性与GDM发病密切相关,G(T突变可能增加妊娠期妇女GDM的发病风险。
[Abstract]:Objective to investigate the relationship between the rs12255372 GT polymorphism of transcription factor 7 analogue 2 (TCF7L2) gene and the risk of gestational diabetes mellitus (GDM) (GDM). Methods as of September 2016, a case-control study on rs12255372 polymorphism and GDM was searched in NCBI Pub Med, China knowledge Network (CNKI) and Wanfang databases. The published bias and heterogeneity of the data included in the Stata12.0 software test were analyzed. OR and 95% confidence interval (95%CI) of combined effect were used to evaluate the risk of rs12255372 and GDM. Results according to inclusion and exclusion criteria, 9 articles including 5778 subjects were included in this study. Meta analysis showed that T allele carriers had significantly higher risk of GDM compared with G genotype. The OR and 95%CI of the whole merger effect were 1.28 (1.16 卤1.40), and the OR and 95%CI of Caucasian population were 1.29 (1.151.45) and 1.25 (1.051.48) respectively. Genotypic analysis showed that rs12255372 GT was significantly correlated with GDM in dominant genetic model. Compared with GG genotype, the incidence of GDM in, GT TT genotype carriers was significantly higher than that in GG genotype. The overall combined effect of OR and 95%CI were 1.35 (1.201.53), 1.39 (1.201.62) in Caucasian population and 1.28 (1.041.58) in Asian population. Conclusion TCF7L2rs12255372 GT polymorphism is closely associated with GDM and, G (T mutation may increase the risk of GDM in pregnant women.
【作者单位】: 桂林医学院公共卫生学院流行病学教研室;桂林医学院第一附属医院;桂林市灵川县人民医院;桂林市妇女儿童医院;桂林医学院第二附属医院;
【基金】:大学生创新创业训练计划项目(201510601079) 广西教育厅高校科研项目(KY2015YB223) 广西科学研究与技术开发计划项目(桂科攻14124004-1-15)
【分类号】:R714.256

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