海南地区女性HLA-DQB1和DRB5基因多态性与宫颈癌易感性的关系

发布时间：2018-11-16 20:27

【摘要】：目的探讨海南地区汉族女性人群中人类白细胞抗原(HLA)-DQB1和HLA-DRB5等位基因多态性与宫颈癌易感性的相关性。方法以海南地区41例经病理确诊的宫颈癌患者和38例因子宫肌瘤行全子宫切除术且病理证实无宫颈癌的患者为研究对象。采用PCR克隆测序技术对两组HLA-DQB1和DRB5等位基因进行分型。结果共检测到12种HLA-DQB1等位基因和8种HLA-DRB5等位基因。其中HLA-DQB1*06011,HLA-DQB1*030101和HLA-DQB1*03032与HLA-DRB5*01:01:01分别是海南地区汉族女性HLA-DQB1和DRB5的优势表达基因。无宫颈癌患者HLA-DRB5*0206等位基因频率(18.4%)显著高于宫颈癌患者(0)(P=0.013)。结论 HLA-DRB5*0206可能是海南地区女性宫颈癌的保护基因,可能降低女性患宫颈癌的风险。HLA-DRB5不同等位基因可能与宫颈癌的发生存在相关性。
[Abstract]:Objective to investigate the association between polymorphisms of human leukocyte antigen (HLA) DQB1 and HLA-DRB5 alleles and susceptibility to cervical cancer in Han women in Hainan area. Methods Forty-one patients with cervical cancer confirmed by pathology and 38 patients with total hysterectomy due to uterine leiomyoma in Hainan area were studied. Two groups of HLA-DQB1 and DRB5 alleles were genotyped by PCR cloning and sequencing. Results 12 HLA-DQB1 alleles and 8 HLA-DRB5 alleles were detected. Among them, HLA-DQB1*06011,HLA-DQB1*030101, HLA-DQB1*03032 and HLA-DRB5*01:01:01 are the dominant expression genes of HLA-DQB1 and DRB5 in Han women in Hainan area, respectively. The frequency of HLA-DRB5*0206 allele in patients without cervical cancer (18.4%) was significantly higher than that in patients without cervical cancer (0) (P0. 013). Conclusion HLA-DRB5*0206 may be a protective gene for cervical cancer in Hainan women and may reduce the risk of cervical cancer in women. Different alleles of HLA-DRB5 may be associated with the occurrence of cervical cancer.
【作者单位】：海南医学院第二附属医院妇产科;海口市人民医院中心实验室;
【基金】：海南省自然科学基金立项项目(编号:813241,817379)
【分类号】：R737.33

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