Megsin基因3个多态性位点与亚洲人群IgA肾病易感性关联的Meta分析

发布时间：2018-12-13 04:07

【摘要】：目的通过Meta分析评估亚洲人群Megsin基因3个多态性位点(rs1055901、rs1055902和rs2689399)与IgA肾病易感性的关联。方法通过中国知网、维普、万方数据库、中国生物医学文献数据库、PubMed、Web of Science和Google学术数据库数据库,电子检索关于亚洲人群Megsin基因rs1055901、rs1055902和rs2689399多态性位点与IgA肾病相关性的研究,检索年限为1960年1月1日开始至2016年5月2日。采用Stata12.0软件计算合并比值比(OR)和95%置信区间(CI),并进行敏感性及发表偏倚分析。结果最终纳入6篇文献(含9项研究),包含2 179例IgA肾病患者和1 769例健康对照。Meta分析结果显示,Megsin基因rs1055901、rs1055902多态性位点与亚洲人群IgA肾病易感性无明显关联。然而,Megsin基因rs2689399位点与亚洲人群IgA肾病易感性呈显著负相关(G和C:OR=0.754,95%CI 0.592~0.961,P=0.022;GG和CC:OR=0.506,95%CI0.287~0.892,P=0.019;GG和GC+CC:OR=0.551,95%CI0.316~0.961,P=0.036)。结论 Megsin基因的rs2689399位点的G等位基因、GG基因型可能是亚洲人群IgA肾病的保护因子。
[Abstract]:Objective to evaluate the association between Megsin gene polymorphisms (rs1055901,rs1055902 and rs2689399) and susceptibility to IgA nephropathy by Meta analysis. Methods Electronic retrieval of Megsin gene rs1055901, in Asian population was carried out through China Zhiwang, Weip, Wanfang database, Chinese biomedical literature database, PubMed,Web of Science and Google academic database. A study on the association of rs1055902 and rs2689399 polymorphism with IgA nephropathy was carried out from January 1, 1960 to May 2, 2016. The combined ratio (OR) and 95% confidence interval (CI),) were calculated by Stata12.0 software and the sensitivity and publication bias were analyzed. Results six articles (including 9 studies) were included, including 2 179 patients with IgA nephropathy and 1 769 healthy controls. Meta analysis showed that there was no significant association between Megsin gene rs1055901,rs1055902 polymorphism locus and susceptibility to IgA nephropathy in Asian population. However, the rs2689399 locus of the Megsin gene was negatively correlated with the susceptibility to IgA nephropathy in Asian population (G and C: ORO 0.754, 95 CI 0.592, 0.961GG and CC:OR=0.506,95%CI0.287~0.892,P=0.019;). GG and GC CC:OR=0.551,95%CI0.316~0.961,P=0.036. Conclusion the G allele and GG genotype of rs2689399 locus of Megsin gene may be the protective factors of IgA nephropathy in Asian population.
【作者单位】：安徽医科大学北京大学深圳医院临床学院;北京大学深圳医院肾内科;
【基金】：深圳市科技研发资金(JCYJ20140415162543010)
【分类号】：R692.3

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