PSCA rs2294008基因变异对膀胱癌分级、分期的影响

发布时间：2019-07-13 20:29

【摘要】：目的研究PSCA rs2294008多态性是否与膀胱癌易感性相关。方法抽取235例膀胱癌患者和200例非膀胱癌患者的血样,进行基因型测定,确定患者血样中PSCA rs2294008基因型,进行病例对照研究。结果 rs2294008的基因型CC、CT和TT在膀胱癌患者中出现的概率分别为42.1%、47.7%、10.2%,在对照组中分别为52.0%、40.0%、8.0%;合并的CT/TT和CC基因型对比,合并基因型使膀胱癌风险显著增加(CT/TT:OR=1.37,95%CI 1.08~1.74)。结论PSCA中rs2294008的基因多态性与膀胱癌的风险相关。
[Abstract]:Objective to study whether PSCA rs2294008 polymorphism is associated with susceptibility to bladder cancer. Methods the blood samples of 23 patients with bladder cancer and 200 patients with non-bladder cancer were collected and genotypic determination was carried out to determine the PSCA rs2294008 genotype in the blood samples of patients with bladder cancer and to carry out a case-control study. Results the probabilities of CC,CT and TT in patients with bladder cancer were 42.1%, 47.7% and 10.2%, respectively, and those in the control group were 52.0%, 40.0% and 8.0%, respectively. The combined CT/TT and CC genotyping significantly increased the risk of bladder cancer (CT/TT:OR=1.37,95%CI 1.08 卤1.74). Conclusion rs2294008 gene polymorphism in PSCA is associated with the risk of bladder cancer.
【作者单位】： 云南省第一人民医院泌尿外科;
【基金】：国家自然科学基金地区基金项目(81260375)
【分类号】：R737.14
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本文编号：2514267