统计分析在溃疡性结肠炎临床试验中的应用

发布时间：2018-03-16 02:00

本文选题：临床试验　切入点：溃疡性结肠炎　出处：《华东师范大学》2017年硕士论文　论文类型：学位论文

【摘要】：新药在上市之前都会在动物或人体进行大量的科学实验,以证实药物的安全性和有效性。在这些临床试验背后,是一个庞大的数据网络,对各项测量数据的正确处理显得尤为重要。掌握适用的统计分析工具,对理解临床研究中实验数据的规律,给出合理的治疗方法,提高解决实际问题能力都有着重要作用。本文通过多种统计方法对溃疡性结肠炎临床数据进行一系列基本信息分析、相关分析、线性回归分析,对重复测量数据进行纵向模型分析。并对试验药物的整体疗效做中期分析,如果药效欠佳则考虑修正设计方案或者终止试验。通过合理的统计分析和假设,提高研究质量,减少不必要的投入成本和时间消耗,做到高效、快速和经济。根据研究统计分析的相关技术,认识到其在医学领域中的应用范围将会越来越广泛,统计方法与医学技术相结合所带来的整体效益将会更多更可观,对疾病防治担负着高度的社会责任。
[Abstract]:New drugs do a lot of scientific experiments in animals or humans before they go on the market to prove their safety and effectiveness. Behind these clinical trials, there's a huge data network. It is very important to correctly deal with the measured data. To grasp the applicable statistical analysis tools, to understand the rule of experimental data in clinical research, and to give a reasonable treatment method, It is important to improve the ability to solve practical problems. In this paper, a series of basic information analysis, correlation analysis, linear regression analysis are carried out on the clinical data of ulcerative colitis by various statistical methods. The longitudinal model analysis of repeated measurement data was carried out. The overall efficacy of the trial drug was analyzed in the medium term. If the efficacy of the drug was poor, the design scheme was revised or the test was terminated. The quality of the research was improved by reasonable statistical analysis and hypothesis. Reducing unnecessary input costs and time consumption and achieving efficiency, speed and economy. Based on the relevant technologies for research and statistical analysis, it is recognized that their application in the field of medicine will become more and more widespread, The combination of statistical method and medical technology will bring more and more benefits, and will bear a high degree of social responsibility for disease prevention and treatment.
【学位授予单位】：华东师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O213

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