纳米纤维对间充质干细胞的影响:影响细胞粘附和成骨分化的环境因素及其机理（英文）
发布时间：2021-03-23 16:47
纳米纤维可以建造适合细胞生长的环境,这种仿生性能促进了纳米纤维材料的广泛应用。在这篇综述中,我们检索了相关研究,并归纳总结了纳米纤维对间充质干细胞的影响,以及影响细胞粘附和成骨分化的因素。我们假设:体外的骨再生过程与体内骨形成和愈合的过程类似;纳米纤维或其支架材料与天然骨组织越接近,骨再生过程就越好。通常,在纳米纤维上培养的细胞具有与体外成骨诱导下的细胞相似的基因表达模式和成骨分化。在此过程中,诸多基因通路表达相继上调（例如,与细胞粘附有关的基因FAK（黏着斑激酶）、与细胞骨架变化和成骨分化有关的基因通路转化生长因子-β（TGF-β）/骨形态发生蛋白（BMP）、促分裂原活化蛋白激酶（MAPK）和Wnt等）。细胞粘附和成骨分化可能受到多种因素的影响。纳米纤维的某些物理性质能够促进细胞粘附和生长,包括合适的亲水性、孔隙率和溶胀性。此外,纳米纤维的硬度在细胞命运中起着至关重要的作用,在较坚硬的支架上,成骨细胞的募集往往更好,其中整合素和YAP/TAZ信号通路与之密切相关。同时,纳米纤维的分层排列结构以及它们与功能性添加剂（生长因子、羟基磷灰石颗粒等）的组合也有助于成骨和骨再生。总而言之,在检...
【文章来源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2020,21(11)SCICSCD
【文章页数】：14 页
【文章目录】：
1 Introduction
2 Structure of bone extracellular matrix
3 Nanofiber characteristics
3.1 Mimicking natural tissue structure
3.2 Physical and structural supports
3.3 Combination with other components
4 Effect of nanofibrous scaffolds on mesen-chymal stem cells
4.1 Overall pattern of cell behavioral mechanisms on nanofiber
4.2 Factors that improve cell adhesion and osteogenesis
4.2.1 Stiff nanofibers promoting cell adhesion and osteogenesis through altering cell tension
4.2.2 Aligned nanofibers enhancing osteogenic gene expression
4.2.3 Hierarchical structure of nanofibrous scaffolds improving cell adhesion and osteogenesis
4.2.4 Other physical and chemical properties of nanofibers
4.2.5 Functional additives in nanofibrous scaffolds
5 Conclusions and future perspectives
Contributors
Compliance with ethics guidelines
【参考文献】：
期刊论文
[1]YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling[J]. Jin-Xiu Pan,Lei Xiong,Kai Zhao,Peng Zeng,Bo Wang,Fu-Lei Tang,Dong Sun,Hao-han Guo,Xiao Yang,Shun Cui,Wen-Fang Xia,Lin Mei,Wen-Cheng Xiong. Bone Research. 2018(02)
[2]Smart scaffolds in bone tissue engineering: A systematic review of literature[J]. Saeed Reza Motamedian,Sepanta Hosseinpour,Mitra Ghazizadeh Ahsaie,Arash Khojasteh. World Journal of Stem Cells. 2015(03)
本文编号：3096102
【文章来源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2020,21(11)SCICSCD
【文章页数】：14 页
【文章目录】：
1 Introduction
2 Structure of bone extracellular matrix
3 Nanofiber characteristics
3.1 Mimicking natural tissue structure
3.2 Physical and structural supports
3.3 Combination with other components
4 Effect of nanofibrous scaffolds on mesen-chymal stem cells
4.1 Overall pattern of cell behavioral mechanisms on nanofiber
4.2 Factors that improve cell adhesion and osteogenesis
4.2.1 Stiff nanofibers promoting cell adhesion and osteogenesis through altering cell tension
4.2.2 Aligned nanofibers enhancing osteogenic gene expression
4.2.3 Hierarchical structure of nanofibrous scaffolds improving cell adhesion and osteogenesis
4.2.4 Other physical and chemical properties of nanofibers
4.2.5 Functional additives in nanofibrous scaffolds
5 Conclusions and future perspectives
Contributors
Compliance with ethics guidelines
【参考文献】：
期刊论文
[1]YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling[J]. Jin-Xiu Pan,Lei Xiong,Kai Zhao,Peng Zeng,Bo Wang,Fu-Lei Tang,Dong Sun,Hao-han Guo,Xiao Yang,Shun Cui,Wen-Fang Xia,Lin Mei,Wen-Cheng Xiong. Bone Research. 2018(02)
[2]Smart scaffolds in bone tissue engineering: A systematic review of literature[J]. Saeed Reza Motamedian,Sepanta Hosseinpour,Mitra Ghazizadeh Ahsaie,Arash Khojasteh. World Journal of Stem Cells. 2015(03)
本文编号：3096102
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