睾酮相关基因对利他人格和行为的影响

发布时间：2018-03-01 23:23

本文关键词： 利他人格利他行为睾酮功能性多态位点　出处：《西北大学》2017年硕士论文　论文类型：学位论文

【摘要】：人体血清睾酮水平与社会行为的关系研究表明,睾酮能够抑制共情,促进攻击行为。但目前睾酮与利他行为的关系尚未得出确切结论。为了确定睾酮相关基因与利他人格及行为的具体关系,我们选取影响睾酮合成与代谢的芳香化酶基因(CYP19A1)、5-α还原酶2基因(SRD5A2)、雄激素受体基因(AR)和性激素结合球蛋白基因(SHBG),采用社会价值取向问卷、独裁者游戏、分配游戏等实验范式,在734名大学生人群中考察这些基因的5个多态性位点与利他人格和行为之间的关系。结果显示:(1)AR基因的(CAG)n序列重复数多态与SHBG基因的rs727428位点均显著影响利他人格,AR基因的SS基因型与SHBG基因的rs727428位点的CC基因型个体表现出高的利他人格倾向(p=0.009)。(2)在分配游戏中,CYYP1A1基因影响了个体分给自己的总点数。GG型个体分配给自己的点数低于A等位基因携带者(p = 0.006)。在独裁者游戏中,SRD5A2基因边缘影响个体分给对家的分配额。CC型个体分配给对家的金额高于G等位基因携带者(p=0.056)。(3)公正世界信念的强度调节基因对分享行为的影响。在公正世界信念水平较高时,CYYP1A1基因的rs700518位点的GG基因型个体和SRD5A2基因的rs523349位点的CC基因型个体表现出更少的分享行为;在公正世界信念水平较低时,这两种基因型个体表现出更多的分享行为。本研究证明利他人格和利他行为受睾酮相关基因的影响:AR基因与SHBG基因影响利他人格;CYP19A以基因与SRD5A2基因影响利他行为。该结果为解释睾酮与亲社会行为的关系提供了一定的实验证据。
[Abstract]:Studies on the relationship between serum testosterone levels and social behavior have shown that testosterone inhibits empathy. But the relationship between testosterone and altruism has not yet been concluded. In order to determine the specific relationship between testosterone related genes and altruistic personality and behavior, We selected the aromatase gene, CYP19A1H5- 伪 reductase 2 gene, androgen receptor gene (ARA) and sex hormone binding globulin gene (SHBGG), which affect testosterone synthesis and metabolism. We used social value orientation questionnaire, dictators' game, distribution game and other experimental paradigms. The relationship between the five polymorphic loci of these genes and altruistic personality and behavior was investigated in 734 college students. The results showed that the repeat polymorphism of SHBG gene and the rs727428 locus of SHBG gene had significant effects on altruistic personality. The SS genotype of AR gene and the CC genotype of rs727428 locus of SHBG gene showed high altruistic personality tendency.) in the distribution game, CYYP1A1 gene affected the total points assigned to individuals. GG type individuals assigned low points to themselves. In the dictators' game, the edge of SRD5A2 gene affects the distribution of individuals to the right family. The amount of money allocated to the right family by the CC type individuals is higher than that of the G allele carriers (p0. 056. 3) the intensity of the fair world belief is regulated. GG genotype individuals of CYYP1A1 gene and CC genotype individuals of SRD5A2 gene rs523349 loci showed less sharing behavior when the level of belief in the fair world was higher than that in the GG genotype of CYYP1A1 gene and the CC genotype at the rs523349 site of the SRD5A2 gene. When the level of faith in the just world is low, This study shows that altruistic personality and altruistic behavior are affected by testosterone related genes: AR gene and SHBG gene. CYP19A gene and SRD5A2 gene influence altruism behavior. The results provide some experimental evidence to explain the relationship between testosterone and prosocial behavior.
【学位授予单位】：西北大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：B848;Q987

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