实脾消水膏外敷治疗原发性肝癌腹水的临床疗效观察

发布时间：2018-03-20 06:20

本文选题：原发性肝癌腹水　切入点：实脾消水膏　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨实脾消水膏外敷治疗原发性肝癌腹水的临床疗效及安全性。方法:将符合纳入标准的63例原发性肝癌腹水患者随机分为试验组(西医常规治疗+实脾消水膏外敷)31例,对照组(西医常规治疗)32例,疗程为10天。试验结束后评价两组患者腹水分度、腹水疗效、中医症状评分、卡氏评分、平均24小时尿量、腹围、体重、量生存质的改善情况,并评价其安全性,比较两组治疗前后有无统计学意义。结果:(1)两组患者治疗前后腹水深度差值、治疗后腹水深度组间比较有统计学意义(P0.05),说明在改善腹水深度方面试验组优于对照组;(2)在改善平均24小时尿量、腹围、体重差值方面,两组治疗前后差值组间比较有显著统计学意义(P0.01),试验组明显优于对照组;(3)在改善生活质量方面:试验组总改善率为83.3%,对照组总改善率为63.3%,治疗后两组比较有统计学意义(P0.05),试验组优于对照组;(4)在常见临床症状方面:两组患者比较无统计学意义(P0.05),其中腹胀、纳呆、下肢水肿方面两组治疗后组间比较有统计学意义(P0.05),试验组优于对照组;在胁痛、恶心呕吐、乏力方面两组治疗后组间比较无统计学意义(P0.05)。在临床观察期间,两组患者均未出现明显不良毒副反应。结论:实脾消水膏外敷治疗原发性肝癌腹水有效、安全,能改善患者生存质量,值得临床推广。
[Abstract]:Objective: to investigate the clinical efficacy and safety of shipixiaoshui ointment in the treatment of ascites of primary liver cancer. Methods: 63 patients with ascites of primary liver cancer were randomly divided into experimental group (western medicine routine treatment of solid spleen). 31 cases of external application of Xiaoshui ointment, In the control group, 32 patients were treated with routine western medicine for 10 days. The improvement of ascites grade, ascites curative effect, TCM symptom score, Karschoff score, average 24 hours urine volume, abdominal circumference, weight and quality of life were evaluated after the trial. The safety of the two groups was evaluated and the difference of ascites depth before and after treatment was compared between the two groups. There was statistically significant difference in the depth of ascites between the two groups after treatment, which indicated that the experimental group was superior to the control group in improving the depth of ascites (P 0.05)) in improving the average 24-hour urine volume, abdominal circumference and weight difference. The difference between the two groups before and after treatment was statistically significant (P 0.01), the experimental group was significantly better than the control group in improving the quality of life: the total improvement rate of the trial group was 83.3%, and the total improvement rate of the control group was 63.3%. After treatment, there were statistics between the two groups. The clinical symptoms in the experimental group were better than those in the control group. There was no significant difference between the two groups in terms of clinical symptoms, in which abdominal distension was found. After treatment, there was no significant difference between the two groups in terms of hypochondriac pain, nausea, vomiting and fatigue. During the period of clinical observation, there was no significant difference between the two groups. Conclusion: Shipixiaoshui ointment is effective and safe in the treatment of ascites of primary liver cancer and can improve the quality of life of patients and is worthy of clinical promotion.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.7

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