血浆同型半胱氨酸水平与急性白血病易栓症关系的研究

发布时间：2018-06-16 22:54

  本文选题：同型半胱氨酸 + 急性白血病　； 参考：《青海大学》2017年硕士论文

【摘要】：目的:通过检测Hcy,同时检测AT-III及DD含量在AL患者化疗前后改变情况,研究Hcy与AT-III、DD之间的相关性,探讨Hcy在AL合并易栓症中的意义。方法:AL组共30例,自2015年11月至2017年2月在青海大学附属医院诊断初治AL患者;其中包括23例AML(非M3)和7例ALL。AL组根据化疗后结局,分为两组:AL缓解组20例;AL未缓解组:10例。对照组30例,为健康体检者。检测AL组化疗前、经标准方案化疗后(恢复期)Hcy、AT-III和DD表达水平;结合文献发现上述指标与高肿瘤负荷可能有一定联系,因此我们检测化疗前LDH含量及血常规,收集记录WBC;对照组于就诊时检测Hcy、AT-III及DD。应用SPSS21.0进行数据的统计分析,各组间比较采用单因素方差分析;同组化疗前后比较采用配对样本t检验;指标间相关性为直线相关分析。检验水准α=0.05。结果:1.AL组化疗前Hcy、DD表达水平均较对照组高,但AT-III含量较对照组低。2.化疗前AL未缓解组Hcy、DD含量较缓解组高,而AT-III较缓解组低。3.化疗后AL缓解组Hcy、DD含量较化疗前低,而AT-III含量较化疗前高;AL未缓解组化疗后Hcy、AT-Ⅲ、DD含量较化疗前无明显差异。4.在化疗前AL患者中,Hcy与AT-III两者存在直线相关关系,为负相关(r=-0.419,P=0.021);Hcy与DD两者存在直线相关关系,为正相关(r=0.612,P=0.000);Hcy与LDH两者存在直线相关关系,为正相关(r=0.407,P=0.025);Hcy与WBC不存在相关性(r=0.340,P=0.066)。结论:1.AL患者化疗前Hcy、AT-III、DD表达异常,并发易栓症的风险增加。2.AL患者化疗前Hcy水平分别与AT-Ⅲ、DD和LDH存在线性相关关系。3.AL未缓解组化疗前后Hcy、AT-Ⅲ及DD水平变化不明显,仍应加强对AL化疗后未缓解患者合并易栓症的重视;而AL缓解组化疗后Hcy、AT-Ⅲ及DD恢复正常水平,合并易栓症的风险逐渐降低。
[Abstract]:Objective: to study the correlation between Hcy and AT-IIIN DD by detecting the changes of AT-III and DD in AL patients before and after chemotherapy, and to explore the significance of Hcy in AL patients with thrombotic disease. Methods from November 2015 to February 2017, 30 patients with primary AL were diagnosed in the affiliated Hospital of Qinghai University, including 23 AMLs (non-M3) and 7 ALL.AL patients. According to the outcome of chemotherapy, they were divided into two groups: 20 cases of non-remission group (n = 20) and 10 cases of non-remission group (n = 10). The control group (30 cases) was healthy. Before and after chemotherapy, the expression levels of Hcyl AT-III and DD were detected in AL group (convalescent stage), and combined with the literature, it was found that the above indexes might be related to high tumor load, so we detected LDH content and blood routine before chemotherapy. The records of WBCwere collected and the control group was examined for Hcytin AT-III and DD. SPSS 21.0 was used to carry out statistical analysis of data, single factor ANOVA was used for comparison among groups, matched sample t test was used for comparison before and after chemotherapy in the same group, and linear correlation analysis was used among the indexes. The test level is 伪 0. 05. Results 1. The expression of Hcyn DD in AL group was higher than that in control group before chemotherapy, but AT-III was lower than that in control group. Before chemotherapy, the level of Hcyn DD in AL without remission group was higher than that in remission group, but AT-III was lower than that in remission group. After chemotherapy, the content of Hcytin DD in AL remission group was lower than that before chemotherapy, and the content of AT-III was higher than that before chemotherapy. There was no significant difference in DD content of Hcyn AT- 鈪，

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