高血压合并糖尿病患者血管内皮功能的临床研究

发布时间：2018-08-06 21:40

【摘要】：目的:通过检测高血压(HP)患者、糖尿病(DM)患者、高血压合并糖尿病患者、健康人群的血清ADMA、NO及CIMT、FMD的测量值,比较这四组数据的变化。并探讨NO和ADMA水平的相关性,为评估HP及DM的病情进展、治疗方案及疾病预防提供了理论依据。方法:对入选的120例研究对象,其中HP组31例,DM组32例,HP合并DM组28例,健康人群29例作为对照组,所有的研究对象行颈动脉彩超、FMD检查,并采集这120例研究对象的血液标本,集中检测血清FPG、LDL、HDL、TG、TC及ADMA、NO的水平,并分析数据。结果:1.⑴各组在性别、年龄、HDL、LDL、TG、TC方面,无显著性差异(P0.05);⑵HP组与HP合并DM组,组间的SBP、DBP无统计学差异(P0.05),与健康组及DM组比较具有差异性(P0.05);⑶DM组与HP合并DM组,组间的FPG均无统计学差异(P0.05),与HP组及健康组比较具有差异性(P0.05)。2.⑴HP组ADMA、CIMT水平均高于健康组P0.05,NO、FMD水平均低于健康组P0.05;⑵DM组ADMA、CIMT水平均高于健康组P0.05,NO、FMD水平均低于健康组P0.05;⑶HP合并DM组ADMA、CIMT水平均高于健康组P0.05,NO、FMD水平均低于健康组P0.05;⑷HP合并DM组ADMA,CIMT水平均高于HP组P0.05,NO、FMD水平均低于HP组P0.05。3.Pearson分析示:血清NO和ADMA成负相关(P0.001);NO、FMD均与SBP、DBP、FPG水平呈负相关(P0.05)CIMT、ADMA均与SBP、DBP、FPG水平呈负相关(P0.05)。结论:1.HP、DM患者存在血管内皮功能损伤,HP合并DM患者较单纯HP患者、单纯DM患者血管内皮损伤更为严重。2.血清NO和ADMA成负相关,提示ADMA是血管内皮损伤的一种危险因子。3.早期通过检测NO、ADMA、FMD、CIMT的水平可以评估血管内皮的功能状态,为及早干预血管内皮损伤提高理论依据。
[Abstract]:Objective: To compare the measured values of serum ADMA, NO and CIMT, FMD in patients with hypertension (HP), diabetes (DM), hypertension and diabetes, and to compare the changes of the four groups of data and to explore the correlation between the level of NO and ADMA, and provide a theoretical basis for evaluating the progression of HP and DM, the treatment scheme and the prevention of disease. 120 subjects were selected, of which 31 cases in group HP, 32 cases in group DM, 28 in group HP with DM, 29 in healthy people as control group. All the subjects were performed carotid artery color Doppler ultrasound, FMD examination, and collected blood specimens of these 120 subjects. The level of serum FPG, LDL, HDL, TG, TC and ADMA, NO level, and data were analyzed. The results were 1. (1, 1) in each group. There was no significant difference in sex, age, age, HDL, LDL, TG, and TC. (2) HP group and HP combined DM group, SBP and DBP were not statistically different between groups (P0.05), and they were different from those of the healthy group and the DM group. Group ADMA, CIMT level were higher than that of healthy group P0.05, NO, FMD level were lower than that of healthy group P0.05. (2) DM group ADMA, CIMT level was higher than that of health group P0.05, NO, and FMD levels were lower than that of the healthy group. The levels of.05, NO and FMD were lower than the P0.05.3.Pearson analysis in group HP, and the serum NO and ADMA were negatively correlated (P0.001), NO and FMD were negatively correlated with SBP, DBP, and the levels were negatively correlated. The negative skin damage is more serious in.2. serum NO and ADMA, suggesting that ADMA is a risk factor for vascular endothelial injury,.3. early detection of NO, ADMA, FMD, CIMT levels can evaluate the functional state of vascular endothelium and improve the theoretical basis for early intervention of vascular endothelial injury.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R544.1;R587.1

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