轻中度痤疮患者与正常人面部皮肤生理指标的分析研究
发布时间：2019-03-29 17:26
【摘要】：研究背景寻常痤疮是一种毛囊皮脂腺的慢性炎症性疾病,其发病机制与众多因素有关,也是皮肤科发病率较高的疾病之一。近年来,“皮肤屏障”逐渐成为学者们重要的关注点,因其与皮肤疾病的形成可能存在一定的相关性。随着无创性皮肤生理测试仪器的更新应用,皮肤角质层含水量、经表皮失水量(TEWL)、皮肤油脂、皮肤表面PH值、皮肤色素(黑色素和血红素)含量及皮肤弹性值等多项皮肤生理指标可被有效地检测出来,测试者们可以更为客观直接地了解皮肤状况。越来越多的皮肤生理研究表明,痤疮患者的皮肤屏障功能出现了异常,很多皮肤生理指标数据统计,如角质层含水量、经表皮失水量(TEWL)、皮肤油脂等,与正常人相比,存在明显差异;而且在临床治疗过程中,皮肤生理指标也会发生变化,随着痤疮的治愈,指标会趋向正常、稳定,但也有其它指标暂未发现有明显的差异,需要进一步的研究。因此,越来越多的学者认为皮肤屏障的损伤可能与痤疮的发生发展相关,有效地保护及修复皮肤屏障对控制和治疗痤疮起着重要的作用。研究目的通过对轻中度痤疮患者与正常人面部皮肤各生理指标的测定比较,分析其中的差异,探讨皮肤生理指标的异常与痤疮发生发展的相关性,为今后对痤疮的预防、控制及治疗提供理论基础。研究方法选取114例受试对象,实验组为痤疮患者57例,其中男24例,女33例,平均年龄为22岁;对照组为正常健康志愿者57例,其中男24例,女33例,平均年龄为22岁。运用无创性皮肤生理功能检测仪,对受试者的前额、鼻部、脸颊三个部位,进行角质层含水量、经表皮失水量(TEWL)、皮肤油脂、皮肤表面PH、皮肤黑色素、皮肤血红素以及皮肤弹性的测量,另外,对受试者的眼角只做弹性测量。统计分析痤疮患者与正常人各部位的各项指标的差异。研究结果实验组痤疮患者前额、脸颊的角质层含水量低于对照组正常人,差异有统计学意义(P0.05);实验组痤疮患者前额、脸颊的经表皮失水量(TEWL)高于对照组,差异有统计学意义(P0.05);实验组痤疮患者前额、鼻部、脸颊的皮肤油脂和血红素含量高于对照组,差异有统计学意义(P0.05)。另外,实验组前额、鼻部、脸颊的PH值、黑色素含量、弹性值,鼻部的角质层含水量和经表皮失水量(TEWL),以及眼角的弹性值与对照组相比,差异均无统计学意义(P㧐0.05)。研究结论痤疮患者面部油脂分泌过多,对于前额、脸颊这样的痤疮好发部位,其经表皮失水量(TEWL)和血红素含量高,角质层含水量低,皮肤屏障功能出现损伤,关于痤疮患者面部的黑色素含量、PH值和弹性值与正常人比较,没有明显差异。
[Abstract]:Background Acne vulgaris is a chronic inflammatory disease of hair follicle sebaceous gland. The pathogenesis of acne vulgaris is related to many factors and is one of the diseases with high incidence in dermatology. In recent years, "skin barrier" has gradually become an important concern of scholars, because it may be related to the formation of skin diseases. With the renewal and application of the non-invasive skin physiological testing instrument, the water content of the cuticle of the skin, the water loss of the skin through the epidermis, the (TEWL), oil and the PH value of the skin surface, Skin physiological indexes such as skin pigment (melanin and heme) content and skin elasticity can be effectively detected, and the subjects can get a more objective and direct understanding of the skin condition. More and more studies on skin physiology show that the skin barrier function of acne patients is abnormal. Many skin physiological data statistics, such as water content of cuticle, transepidermis loss of water content of (TEWL), skin oil and so on, are compared with those of normal people. There are obvious differences; And in the course of clinical treatment, the physiological indexes of skin will also change. With the cure of acne, the indexes will tend to be normal and stable, but there are still no obvious differences in other indexes, which need to be further studied. Therefore, more and more scholars believe that the damage of skin barrier may be related to the occurrence and development of acne, and the effective protection and repair of skin barrier play an important role in the control and treatment of acne. Objective to investigate the correlation between the abnormality of skin physiological indexes and the occurrence and development of acne by comparing the physiological indexes of facial skin between patients with mild to moderate acne and normal people, and to prevent acne in the future, and explore the relationship between the abnormality of skin physiological indexes and the occurrence and development of acne, in order to prevent acne in the future. Control and treatment provide a theoretical basis. Methods A total of 114 subjects were enrolled in this study. The experimental group consisted of 57 acne patients (24 males and 33 females with an average age of 22 years) and 57 healthy volunteers (24 males and 33 females with an average age of 22 years) and 57 healthy volunteers (24 males and 33 females with an average age of 22 years). Using the non-invasive skin physiological function detector, the water content of the cuticle, the water content of (TEWL), skin, the melanin of PH, skin on the skin surface, the water content of the cuticle, the water loss of the skin through the epidermis and the melanin of the skin surface of the subjects were measured. Measurements of skin heme and skin elasticity, in addition, subjects' eye angles were measured only by elasticity. Statistical analysis of acne patients and normal people in different parts of the index differences. Results the water content of cuticle in forehead and cheek of acne patients in experimental group was lower than that in control group (P0.05). The (TEWL) of frontal and cheek transepidermal water loss in experimental group was higher than that in control group, the difference was statistically significant (P0.05). The skin fat and heme contents of acne patients in the experimental group were significantly higher than those in the control group (P0.05). In addition, the PH value of forehead, nose, cheek, melanin content, elastic value, water content of the keratinous layer of the nose, (TEWL), and elastic value of the eye angle of the experimental group were compared with those of the control group. There was no significant difference between the two groups (P < 0.05). Conclusion there is too much oil secretion in the face of acne patients. For acne, such as forehead and cheek, the content of (TEWL) and heme in the epidermis is high, the water content in the stratum corneum is low, and the function of skin barrier is damaged. There was no significant difference in facial melanin content, PH and elasticity between acne patients and normal controls.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.733
本文编号：2449735
[Abstract]:Background Acne vulgaris is a chronic inflammatory disease of hair follicle sebaceous gland. The pathogenesis of acne vulgaris is related to many factors and is one of the diseases with high incidence in dermatology. In recent years, "skin barrier" has gradually become an important concern of scholars, because it may be related to the formation of skin diseases. With the renewal and application of the non-invasive skin physiological testing instrument, the water content of the cuticle of the skin, the water loss of the skin through the epidermis, the (TEWL), oil and the PH value of the skin surface, Skin physiological indexes such as skin pigment (melanin and heme) content and skin elasticity can be effectively detected, and the subjects can get a more objective and direct understanding of the skin condition. More and more studies on skin physiology show that the skin barrier function of acne patients is abnormal. Many skin physiological data statistics, such as water content of cuticle, transepidermis loss of water content of (TEWL), skin oil and so on, are compared with those of normal people. There are obvious differences; And in the course of clinical treatment, the physiological indexes of skin will also change. With the cure of acne, the indexes will tend to be normal and stable, but there are still no obvious differences in other indexes, which need to be further studied. Therefore, more and more scholars believe that the damage of skin barrier may be related to the occurrence and development of acne, and the effective protection and repair of skin barrier play an important role in the control and treatment of acne. Objective to investigate the correlation between the abnormality of skin physiological indexes and the occurrence and development of acne by comparing the physiological indexes of facial skin between patients with mild to moderate acne and normal people, and to prevent acne in the future, and explore the relationship between the abnormality of skin physiological indexes and the occurrence and development of acne, in order to prevent acne in the future. Control and treatment provide a theoretical basis. Methods A total of 114 subjects were enrolled in this study. The experimental group consisted of 57 acne patients (24 males and 33 females with an average age of 22 years) and 57 healthy volunteers (24 males and 33 females with an average age of 22 years) and 57 healthy volunteers (24 males and 33 females with an average age of 22 years). Using the non-invasive skin physiological function detector, the water content of the cuticle, the water content of (TEWL), skin, the melanin of PH, skin on the skin surface, the water content of the cuticle, the water loss of the skin through the epidermis and the melanin of the skin surface of the subjects were measured. Measurements of skin heme and skin elasticity, in addition, subjects' eye angles were measured only by elasticity. Statistical analysis of acne patients and normal people in different parts of the index differences. Results the water content of cuticle in forehead and cheek of acne patients in experimental group was lower than that in control group (P0.05). The (TEWL) of frontal and cheek transepidermal water loss in experimental group was higher than that in control group, the difference was statistically significant (P0.05). The skin fat and heme contents of acne patients in the experimental group were significantly higher than those in the control group (P0.05). In addition, the PH value of forehead, nose, cheek, melanin content, elastic value, water content of the keratinous layer of the nose, (TEWL), and elastic value of the eye angle of the experimental group were compared with those of the control group. There was no significant difference between the two groups (P < 0.05). Conclusion there is too much oil secretion in the face of acne patients. For acne, such as forehead and cheek, the content of (TEWL) and heme in the epidermis is high, the water content in the stratum corneum is low, and the function of skin barrier is damaged. There was no significant difference in facial melanin content, PH and elasticity between acne patients and normal controls.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.733
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相关期刊论文 前3条
1 杨珊;伊力扎提·阿布都哈克;普雄明;;痤疮患者与健康者面部生理指标的测定[J];中华医学美学美容杂志;2013年06期
2 吴琰瑜;王学民;程英;谈益妹;袁超;;轻中度痤疮患者皮肤生理参数特征[J];中华皮肤科杂志;2011年06期
3 张璐璐;闵仲生;;寻常性痤疮患者皮肤生理指标的研究[J];中国麻风皮肤病杂志;2008年01期
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