椎动脉型颈椎病患者中医证素分布及其与血清内皮素、超氧化物歧化酶的相关性研究

发布时间：2018-01-05 10:16

本文关键词：椎动脉型颈椎病患者中医证素分布及其与血清内皮素、超氧化物歧化酶的相关性研究　出处：《北京中医药大学》2017年博士论文　论文类型：学位论文

【摘要】：目的:1、探讨椎动脉型颈椎病的中医证素特征,包括病位证素及病性证素特点,以及不同性别、不同年龄段患者病位证素、病性证素的差异性。2、研究椎动脉型颈椎病患者血清内皮素(ET)、血浆超氧化物歧化酶(SOD)的浓度特点以及在不同性别、不同年龄段之间分布的差异性。3、研究椎动脉型颈椎病患者中医证素与血清内皮素、血浆超氧化物歧化酶之间的相关性。方法:按照中医四诊方法采集114例椎动脉型颈椎病患者的四诊资料,根据朱文峰教授《证素辨证学》中病位证素、病性证素诊断标准对四诊资料进行整理分类、统计,明确椎动脉型颈椎病患者的证素特点,分析椎动脉型颈椎病患者的中医证素分布特征。同时检测患者的血清ET、SOD水平,明确椎动脉型颈椎病患者ET、SOD浓度的分布特点。采用Logistic逐步回归分析法分析中医证素与血浆ET、SOD水平的相关性。结果:1、椎动脉型颈椎病证素特点:(1)病位证素及病性证素特点:114例椎动脉型颈椎病患者常见病位证素分布依次为肾脾肝心胃,常见实性证素依次为寒血癖湿热气滞,常见虚性证素依次为气虚阴虚血虚阳虚阳亢。(2)不同性别及年龄之间证素分布特点:男性胃、气滞、阳虚、阳亢证素积分较女性低,湿证素积分较女性高(P0.05)。老年肝证素积分明显小低于中年、血虚证素积分大于中年,中年心证素积分大于青年(P0.05)。2、椎动脉型颈椎病患者ET、SOD的浓度特点:(1)椎动脉型颈椎病患者ET水平明显高于正常人群,SOD水平明显低于正常人群。(2)椎动脉型颈椎病不同性别之间ET及SOD分布无差异性。(3)椎动脉型颈椎病患者不同年龄段之间ET分布存在差异性,SOD分布无明显差异,中年及老年患者ET水平明显高于青年组,中年及老年组之间ET水平无明显差异。3、ET、SOD与证素特点之间相关性:回归分析结果显示,ET为肾、血瘀、热证素的危险因素(0R值分别为1.61、2.72、1.376),SOD为热证素的危险因素(OR值分别为0.513、0.4321)。结论:1、椎动脉型颈椎病中医证素特点:(1)肾、脾、肝为椎动脉型颈椎病的主要病位。(2)椎动脉型颈椎病患者实性证素主要为寒、血瘀、湿,虚性证素主要为气虚、阴虚、血虚。2、椎动脉型颈椎病ET浓度高于正常人群,SOD浓度明显低于正常人群。中年及老年组患者ET浓度高于青年组。3、当患者ET升高时更容易出现肾、血瘀、热的病理变化,当SOD降低时更容易出现胃、湿的病理变化。
[Abstract]:Objective: 1 to explore the TCM syndrome of cervical spondylosis of vertebral artery type element features, including the syndrome elements of disease location and disease syndrome characteristics, and different gender, different age patients with disease syndrome factor, disease syndrome difference.2 of vertebral artery type of cervical spondylosis patients serum endothelial factor (ET). The plasma superoxide dismutase (SOD) concentration and characteristics in different gender, different age differences in the distribution of the.3 of patients with vertebral artery type cervical spondylosis syndrome and serum endothelin, correlation between plasma superoxide dismutase. Methods: to collect diagnostic data of 114 cases of patients with vertebral artery type cervical spondylosis according to the method of TCM syndrome differentiation, according to Professor Zhu Wenfeng "syndrome study on syndrome elements of disease location, disease syndrome diagnostic criteria of diagnostic data classification, statistics, clear characteristics of patients with vertebral artery type of cervical spondylosis syndrome, analysis of patients with cervical spondylosis of vertebral artery type of traditional Chinese Medicine The distribution characteristics of the syndrome elements. At the same time, serum ET, SOD levels were detected, clear ET patients with vertebral artery type of cervical spondylosis, the distribution characteristics of SOD concentration. Logistic regression was used for analysis of TCM syndrome factors and plasma ET, the relationship between the level of SOD. Results: 1. The characteristics of disease and syndrome of cervical vertebral artery: (1) the characteristics of syndrome elements of disease location and disease syndrome: 114 cases of patients with vertebral artery type cervical spondylosis common disease syndrome in spleen and liver kidney heart and stomach, common solid syndrome followed by cold damp heat blood stasis and qi stagnation, common asthenia symptom were Qi Yin deficiency Yang Yang (2). Between different sex and age distribution characteristics: male stomach syndrome, qi stagnation, deficiency of Yang, yang hyperactivity syndrome integral is lower than female, damp syndrome integral is higher than female (P0.05). The elderly liver symptom factors significantly lower than that of the middle-aged, blood deficiency score greater than that of the middle-aged, middle-aged heart syndrome integral youth (greater than P0.05.2), cervical vertebral artery type ET patients with vertebral disease, the concentration characteristics of SOD: (1) patients with vertebral artery type cervical spondylosis ET levels were significantly higher than the normal population, the level of SOD was significantly lower than that of normal people. (2) vertebral artery type of cervical spondylosis of different sex between ET and SOD distribution (3). There was no difference in patients with vertebral artery type of Cervical Spondylosis among different age ET distribution is different, the distribution of SOD had no significant difference in middle-aged and elderly patients with ET was significantly higher than that in the young group, no significant difference between middle-aged and elderly group.3, ET level ET, the correlation between SOD features and syndrome: regression analysis showed that ET is the kidney, blood stasis, heat syndrome risk factors (0R = 1.61,2.72,1.376), SOD is a hot syndrome risk factors (OR = 0.513,0.4321). Conclusion: 1. The characteristics of TCM syndrome of vertebral artery type of cervical spondylosis: (1) kidney, spleen disease, mainly for cervical spondylosis of vertebral artery type of liver. (2) patients with vertebral artery type cervical spondylosis solid syndrome mainly Cold, wet, blood stasis, deficiency syndromes are mainly Qi deficiency, yin deficiency, blood deficiency.2, cervical spondylosis of vertebral artery type ET concentration is higher than the normal population, the concentration of SOD was significantly lower than that of normal people. In middle-aged and elderly patients ET concentration is higher than the young group of.3, ET increased when patients are more prone to renal pathological changes, blood stasis, heat when the SOD is lowered, more prone to stomach, pathological changes of wet.

【学位授予单位】：北京中医药大学
【学位级别】：博士
【学位授予年份】：2017
【分类号】：R274.9

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