解毒方对原发性肝癌肝动脉化疗栓塞术后炎症反应的作用及其分子机制
发布时间：2021-07-08 12:32
目的:通过前瞻性队列研究探索解毒方（Jiedu Fang,JDF）对原发性肝癌患者行肝动脉化疗栓塞术（Transcatheter arterial chemoembolization,TACE）后临床疗效及预后的影响,并明确JDF与TACE术前后患者血清炎症因子变化的关系,同时对其部分作用机制进行初步研究。方法:1.通过前瞻性队列研究,纳入2018年2月至2018年8月于长海医院行TACE术的原发性肝癌患者,分为JDF组与单纯行TACE术的对照组,通过安德森症候评分表评估患者术前24小时、术后24小时、术后72小时的生存质量,分析JDF能否缓解TACE术后栓塞综合征。并于术前、术后第3天、术后2个月抽取外周血检测血常规、肝功能、白介素（Interleukin,IL）-1β等炎症因子水平,分析两组患者炎症因子及基于炎症评分系统分数的变化,通过单变量分析筛选出JDF作用的敏感因子。2.绘制kaplan-Meier生存曲线并通过Log-rank检验比较解JDF组与对照组的术后无疾病进展生存期（Progresstion free survival,PFS）的差别,同时采用COX比例风险模型对T...
【文章来源】：上海中医药大学上海市
【文章页数】：109 页
【学位级别】：博士
【部分图文】：
TACE术后第1天的安德森症候评价表中评分图
JDF对TACE术后综合症的缓解率
20图4TACE术前及术后不同炎症因子含量及炎症指数的变化*代表JDF组与对照组相比P<0.05表7.TACE术前和术后不同水平的GPS、mGPS患者人数分布指标Grade对照组(n)JDF组(n)P值pre-GPS036270.521912222day3-GPS0100.2813223214182mons-GPS023230.811713275pre-mGPS036310.99198222day3-mGPS0110.3813222214182mons-mGPS026280.441148275
【参考文献】：
期刊论文
[1]中药联合肝动脉栓塞化疗术（TACE）治疗原发性肝癌研究进展[J]. 陈亚栋,莫春梅,荣震,应杉,陈星玥. 辽宁中医药大学学报. 2019(01)
[2]升荣口服液联合肝动脉介入化疗栓塞治疗原发性肝癌疗效及机制研究[J]. 喻小静,蔡惠,李强,陈萌,贺启华,范志刚. 中西医结合肝病杂志. 2018(05)
[3]New prognostic biomarkers of mortality in patients undergoing liver transplantation for hepatocellular carcinoma[J]. Leonardo Lorente. World Journal of Gastroenterology. 2018(37)
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[9]High-dose Iodized Oil Transcatheter Arterial Chemoembolization For Patients with Large Hepatocellular Carcinoma[J]. Min-Shan Chen Jin-Qing Li Ya-Qi Zhang Yun-Fei Yuan Yong-Ping Guo Xiao-Jun Lin Guo-Hui Lim Department of Hepatobiliary Cancer Center of Sun Yet-sen University of Medical Sciences,Guangzhou 510060,China Li-Xia Lu Wei-Zhang Zhang Department of Radiology Cancer Center of Sun Yet-sen University of Medical Sciences,Guangzhou 510060,China. World Journal of Gastroenterology. 2002(01)
本文编号：3271575
【文章来源】：上海中医药大学上海市
【文章页数】：109 页
【学位级别】：博士
【部分图文】：
TACE术后第1天的安德森症候评价表中评分图
JDF对TACE术后综合症的缓解率
20图4TACE术前及术后不同炎症因子含量及炎症指数的变化*代表JDF组与对照组相比P<0.05表7.TACE术前和术后不同水平的GPS、mGPS患者人数分布指标Grade对照组(n)JDF组(n)P值pre-GPS036270.521912222day3-GPS0100.2813223214182mons-GPS023230.811713275pre-mGPS036310.99198222day3-mGPS0110.3813222214182mons-mGPS026280.441148275
【参考文献】：
期刊论文
[1]中药联合肝动脉栓塞化疗术（TACE）治疗原发性肝癌研究进展[J]. 陈亚栋,莫春梅,荣震,应杉,陈星玥. 辽宁中医药大学学报. 2019(01)
[2]升荣口服液联合肝动脉介入化疗栓塞治疗原发性肝癌疗效及机制研究[J]. 喻小静,蔡惠,李强,陈萌,贺启华,范志刚. 中西医结合肝病杂志. 2018(05)
[3]New prognostic biomarkers of mortality in patients undergoing liver transplantation for hepatocellular carcinoma[J]. Leonardo Lorente. World Journal of Gastroenterology. 2018(37)
[4]加味大柴胡汤治疗原发性肝癌患者TACE术后综合征的临床观察[J]. 乔喜婷,王克穷,闫明亮,乔秋飞,张兆国,于明洋,王会仓,岳黎明. 中医药导报. 2016(11)
[5]关于“肝之癌毒”理论的简述[J]. 姜家康,陈瑞睿,刘洪星,迟文成. 中医药信息. 2012(04)
[6]Serum HIF-1α and VEGF Levels Pre-and Post-TACE in Patients with Primary Liver Cancer[J]. Zhong-zhi Jia1*,Guo-min Jiang1,and Yao-liang Feng2 1Department of Interventional Radiography,Changzhou Second People’s Hospital Affiliated to Nanjing Medical University,Changzhou 213003,China 2Department of Interventional Radiography,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China. Chinese Medical Sciences Journal. 2011(03)
[7]对“癌毒”定义的再认识[J]. 岳小强. 中西医结合学报. 2010(09)
[8]“癌毒”是恶性肿瘤之根本[J]. 凌昌全. 中西医结合学报. 2008(02)
[9]High-dose Iodized Oil Transcatheter Arterial Chemoembolization For Patients with Large Hepatocellular Carcinoma[J]. Min-Shan Chen Jin-Qing Li Ya-Qi Zhang Yun-Fei Yuan Yong-Ping Guo Xiao-Jun Lin Guo-Hui Lim Department of Hepatobiliary Cancer Center of Sun Yet-sen University of Medical Sciences,Guangzhou 510060,China Li-Xia Lu Wei-Zhang Zhang Department of Radiology Cancer Center of Sun Yet-sen University of Medical Sciences,Guangzhou 510060,China. World Journal of Gastroenterology. 2002(01)
本文编号：3271575
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