增产胺类似物的合成与生物活性研究

发布时间：2018-05-16 04:43

本文选题：增产胺 + 植物生长调节剂　；参考：《青岛科技大学》2017年硕士论文

【摘要】：新型植物生长调节剂增产胺从出现至今,一直是农业学术研究领域的热点,涉及结构改造、合成工艺研究、肥料的复配和剂型的研究等。因其创造的增产奇迹实属惊人,以及环境友好的特点,更是被称为“神奇之药”。药物创制工作也在此基础上展开,获得了许多植物生长调节活性物质,有望产生更大的增产效果。本论文在相关文献和他人的合成经验的基础上,选择最易实施的合成方法合成增产胺以及有吡啶结构的增产胺类似物,进一步探索各类增产胺类似物的合成方法,有利于实现工业化生产。以2,4-二氯苯酚为基本基团,以二乙氨基乙醇和2-吡啶乙醇为拼接基团,得到化合物。通过比较两者的活性,确定吡啶结构的优越性,并探索新的合成方法,合成了13个化合物,均通过核磁、气相质谱等鉴定方法确定结构。测试了其植物生长调节活性,部分化合物超过了增产胺。对植物生长调节活性较为优越的化合物进行剂型研究,获得状态稳定、效果好的优秀配方,并通过进一步大田实验证明了其药效。本文合成了13个增产胺类似物,其中7个是未见报道的新化合物,它们的结构通式如下。并通过小麦、小白菜的发芽生根实验简单测定其促生长原理,发现其具有普遍促进根部生长,特别是侧根生长的作用。其中有四种类似物具有良好的杀菌活性,能起到增产和杀菌的双重作用。筛选出5种效果突出的增产胺类似物,通过微乳剂剂型配方的开发,确保其市场应用前景,通过科学的大田试验证明其结果。
[Abstract]:Since the emergence of new plant growth regulator, the production of amine has been a hot topic in the field of agricultural academic research, involving structural transformation, synthesis technology research, fertilizer compound and dosage form research, and so on. It is also called "magic medicine" because of its amazing miracle of increasing production and its environmental friendliness. On the basis of this, many plant growth regulator active substances were obtained, which is expected to produce greater effect of increasing production. In this paper, based on the relevant literature and other people's synthetic experience, we choose the most suitable synthetic method to synthesize yield amine and its analogues with pyridine structure, and further explore the synthetic methods of all kinds of yield increasing amine analogues. It is propitious to realize industrialized production. The compound was obtained by using 2o 4-dichlorophenol as the basic group, diethylamino ethanol and 2-pyridine alcohol as the splicing groups. The advantages of pyridine structure were determined by comparing their activities, and a new synthetic method was explored. Thirteen compounds were synthesized and identified by NMR and GC-MS. The plant growth regulation activity was tested and some of the compounds exceeded the yield-increasing amine. The formulation of the compounds with superior plant growth regulation activity was studied, and an excellent formula with stable state and good effect was obtained, and its efficacy was proved by further field experiments. In this paper, 13 analogues of yield-increasing amine have been synthesized, of which 7 are new compounds which have not been reported. Their structures are as follows. Through the experiment of germination and rooting of wheat and pakchoi, the principle of promoting growth was determined, and it was found that it could promote root growth, especially lateral root growth. Among them, four analogs have good bactericidal activity and play a dual role of increasing production and sterilizing. Through the development of formulation of microemulsion formulation, the market application prospect was ensured, and the results were proved by scientific field experiments.
【学位授予单位】：青岛科技大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TQ452

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