钠氢交换体的结构、功能及其在疾病中的作用

发布时间：2018-02-20 15:00

本文关键词： 钠氢交换体(NHE) 基因表达分子结构 pH调节　出处：《成都医学院学报》2014年04期 　论文类型：期刊论文

【摘要】：正细胞内pH维持在一定的生理范围内,对细胞的生长分化、细胞内酶的活性、细胞骨架的装配与解聚等生理过程至关重要。细胞主要依赖于一系列离子转运蛋白来调控细胞内pH的动态平衡,钠氢交换体(Na+/H+exchanger,NHE)是其中重要的成员之一。NHE家族共有9个亚型,根据发现顺序依次命名为NHE1~NHE9,具有不同的组织分布和功能特性。近年来研究表明,NHE除能调节细胞内的pH值外,还参与了上皮细胞的盐运输和细胞
[Abstract]:The pH of positive cells is maintained in a certain physiological range, the growth and differentiation of cells, the activity of enzymes in cells, The physiological process of cytoskeleton assembly and depolymerization is very important. Cells mainly depend on a series of ion transporter to regulate the dynamic equilibrium of intracellular pH. The Na / H exchanger NHEE is one of the important members. The NHE family has nine subtypes. According to the order of discovery, NHE1 and NHE9 have different tissue distribution and functional characteristics. Recent studies have shown that NHE not only regulates the pH value of cells, but also participates in the salt transport of epithelial cells and cells.
【作者单位】：南方医科大学生物技术学院;
【基金】：国家自然科学基金(NO:81171608)
【分类号】：R3416

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