高表达Caveolin-1抑制内皮细胞增殖的信号传递机制研究

发布时间：2018-03-08 12:42

本文选题：Caveolin-1　切入点：内皮细胞　出处：《中国医科大学》2005年博士论文　论文类型：学位论文

【摘要】：血管生成(angiogenesis)是指在原有的血管床上产生新血管的过程。它在胚胎发育、伤口修复、组织再生、肿瘤生长等生理、病理过程中起重要作用。血管生成包括内皮细胞增殖、迁移、分化等过程,其中内皮细胞增殖是血管生成的关键步骤。内皮细胞增殖是在促血管生成因子和抑制血管生成因子以及细胞外基质的共同作用下发生的。迄今为止,已发现了一系列促血管生成因子,如VEGF(血管内皮生长因子)、FGF(成纤维细胞生长因子)、EGF(表皮生长因子)等。其中VEGF
[Abstract]:Angiogenesis (angiogenesis) refers to the process of generating new blood vessels in the vascular bed of the original. It is in the embryonic development, wound healing, tissue regeneration, tumor growth and physiology, plays an important role in the pathological process. Angiogenesis including endothelial cell proliferation, migration, differentiation, and proliferation of endothelial cells is a key step in angiogenesis the proliferation of endothelial cells in angiogenesis and inhibition of angiogenesis factor and the interaction of the extracellular matrix of the.
So far, a series of angiogenic factors, such as VEGF (vascular endothelial growth factor), FGF (EGF) and epidermal growth factor (VEGF), have been discovered.

【学位授予单位】：中国医科大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R363

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