人脑纹状体边缘区的临床和功能磁共振成像研究

发布时间：2018-04-04 14:02

本文选题：人　切入点：纹状体　出处：《第一军医大学》2005年博士论文

【摘要】：1988年舒斯云等在研究大鼠脑纹状体时发现的位于新纹状体尾内侧、靠近苍白球边缘的一个由梭形细胞构成的新亚区,富含多种神经肽类阳性纤维、终末和胞体,并命名为纹状体边缘区。在随后的研究中又陆续发现猫和猴脑内也存在类似的纹状体边缘区。双盲Y迷宫试验和即早基因c-fos表达法等均证实纹状体边缘区参与了大鼠的学习记忆过程。但人脑纹状体内是否也存在边缘区?其形态结构和功能如何?与人的学习、记忆功能是否有关?为探讨这些问题我们首先采用神经细胞形态染色方法证实了边缘区在人脑纹状体内的存在,接着通过观察脑大体解剖标本、数字减影脑血管成像(DSA)、MRI及MRA,发现供应脑纹状体区的血管丰富,在此基础上,利用功能磁共振成像(functional magnetic resonance imaging,fMRI)技术对正常人脑的边缘区是否具有学习记忆功能进行了研究,证实了人脑边缘区参与了视觉数字工作记忆、计算力、过程;然后,我们还对50例边缘区损伤患者的脑部MRI进行分析,发现这些患者均存在不同程度的认知功能障碍,通过测定边缘区损伤患者的简易智能状态检查量表(Mini-Mental State Examination,MMSE)评分及特殊临床病例报告,结合磁共振影像学分析,从临床角度探讨了人脑边缘区与学习记忆等认知功能的关系。
[Abstract]:In 1988, Shu et al found in the striatum of rats in the new striatum, a spindle cell component of globus pallidus Xinya area close to the edge, rich in a variety of neuropeptides immunoreactive fibers, terminals and cell bodies, and named the striatum. In later studies have found there is a similar MRD cat and monkey brain. Double blind Y maze test and c-fos expression method confirmed that the MRD involved in learning and memory in rats. But the brain striatum whether there is a fringe? How about its structure and shape and people's learning, memory? The function is about? That fringe in the human striatum exists to discuss these problems we used morphological neural cell staining method, followed by observation of brain anatomy specimens, digital subtraction angiography (DSA), MRI And MRA, that striatum rich blood vessels, on this basis, using functional magnetic resonance imaging (functional magnetic resonance imaging, fMRI) or fringe technology on the normal human brain has the function of learning and memory were studied, confirmed brain limbic regions involved in visual digital working memory, computing power, and process; we are also on the brain MRI in 50 patients with fringe injury were analyzed and found that these patients have different cognitive impairments, through the determination of patients with borderline lesions MMSE (Mini-Mental State, Examination, MMSE) score and special clinical case reports, analysis combined with magnetic resonance imaging, to explore the relationship of human brain the edge area and cognitive functions such as learning and memory from the clinical point of view.

【学位授予单位】：第一军医大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R322;R445.2

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