T细胞亚群及相关免疫分子在生理性衰老过程中的调节性表达及其意义

发布时间：2018-04-10 00:19

本文选题：生理性衰老　切入点：免疫机制　出处：《苏州大学》2005年硕士论文

【摘要】：生理性衰老(Aging or Senescence)是指伴随年龄增长的全方位多系统的由基因严格控制的循序渐进的生理性的自然过程,其普遍性、内因性、进行性及有害性作为衰老的标准被普遍接受。在长期的对于衰老机制的探索过程中形成了各种流派、众多假说,而免疫功能降低导致机体衰老的假说愈来愈引起人们的关注。许多研究表明老年人较年轻人更易于感染各种疾病,尤其机体对从未接触过的新的抗原物质免疫应答明显降低,而疾病的发生发展不仅使得老年群体生活质量下降,甚至有可能威胁生命,成为机体生理性衰老的重要原因之一。虽然免疫功能的降低在疾病的发生发展中起重要作用已为大家接受,但对于其在生理性衰老过程中作用的机制尚未完全明了。最近的研究显示,与年轻个体相比较,老年群体T细胞亚群发生了明显变化,表现为CD3+T细胞、CD4+T细胞降低,而CD8+T细胞百分数增高,初始T细胞降低而记忆T细胞增加,CD28在老年人T细胞上的表达降低,血浆中IL-2水平下降,而对于IL-4及IL-6大部分的观点认为伴随年龄增高而增高,但也有持不同观点者。本研究进一步观察了T细胞及其各亚群的相对数及绝对数在生理性衰老过程中的变化,CD28分子在不同T细胞亚群上的表达以及可溶性
[Abstract]:Physiologic aging Aging or senescence refers to an all-directional, multi-system, genetically controlled, gradual and natural process of aging, whose universality, internal causes, progression and harmfulness are generally accepted as the criteria for aging.In the long process of exploring the mechanism of aging, various schools and many hypotheses have been formed, and the hypothesis that the decline of immune function leads to the aging of the body has attracted more and more attention.Many studies have shown that older people are more susceptible to various diseases than young people, and that the immune response of the body to new antigen substances that have never been exposed to is significantly reduced, and that the occurrence and development of the disease not only lead to a decline in the quality of life of the elderly population,It may even threaten life and become one of the important reasons of physiological senescence.Although the decrease of immune function plays an important role in the occurrence and development of disease, the mechanism of its role in physiologic senescence has not been fully understood.Recent studies have shown that, compared with young individuals, T cell subsets in the elderly population have changed significantly, showing that CD3 T cells have decreased CD4 T cells, while the percentage of CD8 T cells has increased.The expression of CD28 on T cells was decreased and the level of IL-2 in plasma was decreased. However, most of the views of IL-4 and IL-6 were related to the increase of age, but there were different views.The changes of relative numbers and absolute numbers of T cells and their subgroups during physiological senescence were further studied. The expression of CD28 molecules on different T cell subsets and their solubility were observed.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R392

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