口腔肿瘤患者精神心理因素评估及相关物质基础的初步研究

发布时间：2018-06-26 01:49

本文选题：症状自评量表 + 口腔肿瘤　；参考：《华西口腔医学杂志》2014年01期

【摘要】：目的认识口腔肿瘤患者及配偶的精神心理因素变化规律,探索其相关物质基础。方法选取2011年12月—2012年8月间四川大学华西口腔医院确诊的口腔恶性肿瘤患者40例、良性肿瘤患者35例、恶性肿瘤配偶18例,应用症状自评量表(SCL90)按照5级评分标准,测评每位受试者精神心理状况。于入院次日上午9点抽取受试者的全血,分离提取血清,采用高效液相色谱-质谱分析血清中儿茶酚胺以及糖皮质激素含量。结果恶性肿瘤组强迫症状、抑郁与其他因子分均高于良性肿瘤组,差异有统计学意义(P0.05);恶性肿瘤组强迫症状、偏执与恐怖因子分均高于恶性肿瘤配偶组,差异有统计学意义(P0.05)。各组间总分及其他单项因子分差异无统计学意义。血清中肾上腺素、去甲肾上腺素、氢化可的松及可的松的检测中,恶性肿瘤组与良性肿瘤组、恶性肿瘤配偶组间差异均有统计学意义(P0.001)。结论口腔肿瘤患者存在明显的精神心理因素变化,同时伴有机体内相关物质变化,影响着恶性肿瘤的发生发展,对进一步研究恶性肿瘤疾病进程的相关机制及探索干预方法有重要价值。
[Abstract]:Objective to investigate the changes of mental and psychological factors in patients with oral tumor and their spouses. Methods from December 2011 to August 2012, 40 patients with oral malignant tumor, 35 patients with benign tumor and 18 spouses with malignant tumor were selected from Huaxi Stomatological Hospital of Sichuan University. The symptom Checklist 90 (SCL90) was applied according to grade 5 score. The mental and psychological status of each of the subjects was evaluated. The whole blood was collected at 9 o'clock in the morning of admission and the serum was isolated and extracted. The contents of catecholamine and glucocorticoid in serum were determined by high performance liquid chromatography-mass spectrometry (HPLC / MS). Results the scores of obsessive-compulsive symptoms, depression and other factors in malignant tumor group were higher than those in benign tumor group (P0.05), and the obsessive-compulsive symptoms, paranoid ideation and phobic factor scores in malignant tumor group were higher than those in malignant spouse group (P0.05). There was no significant difference in total score and other single factor scores among groups. In the detection of serum adrenaline, norepinephrine, hydrocortisone and cortisone, there were significant differences between malignant tumor group, benign tumor group and malignant spouse group (P0.001). Conclusion there are obvious changes of psycho psychological factors in patients with oral cancer, accompanied by changes of related substances in the body, which affect the occurrence and development of malignant tumors. It is of great value to further study the mechanism of malignant tumor disease process and explore the intervention methods.
【作者单位】：口腔疾病研究国家重点实验室华西口腔医院头颈肿瘤外科(四川大学);四川大学华西第二医院病案管理科;四川大学华西公共卫生学院卫生检验学教研室;卫生统计教研室;
【基金】：国家自然科学基金资助项目(81172578) 国家大学生创新训练计划基金资助项目(201210610096)
【分类号】：R395

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