中国人群HIV-1B亚型特异性CTL应答研究和HLA-All类分子限制的CTL表位确定

发布时间：2018-07-08 08:48

本文选题：I型人免疫缺陷病毒 + 人获得性免疫缺陷综合征　；参考：《第四军医大学》2006年博士论文

【摘要】：获得性免疫缺陷综合征(AIDS)绝大多数是由Ⅰ型人类免疫缺陷病毒(HIV-1)引起的全球流行的传染病，并成为人类主要的致死性疾病之一。据2005年联合国艾滋病规划署和世界卫生组织的最新估计，自1981年首次发现HIV-1感染者以来，全球感染者累计7，000万人以上，现存人数4，，030万，每年约新增感染者490万。高效抗逆转录病毒疗法(HAART)虽能降低部分患者病毒含量，延缓病情发展，改善症状，但因费用高、药物副作用大使许多患者难以耐受，也不能为大多数患者接受(特别是发展中国家患者)，更为重要的是HAART不能完全清除病毒。所以寻找有效HIV-1疫苗是目前迫切解决的问题。大量研究证明细胞免疫特别是HIV-1特异性CTL应答反应在控制HIV-1感染中起关键作用。故研发以增强HIV-1特异性CTL效应为目的的疫苗具有很大潜力。开发此类疫苗首要的任务是确定能诱导强的HIV-1特异性CTL应答并具有广泛免疫原性的特异性表位。有效的HIV-1特异性CTL应答不仅由抗原结构决定，同时受到HLA-Ⅰ等位基因限制，可见，筛选和鉴定具有强的和广泛作用的HIV-1特异性CTL表位其中研究表位的HLA-Ⅰ类分子限制性是不可缺少的工作。不同人群HLA-Ⅰ等位基因的分布频率不同，决定不同人群对HIV-1的CTL应答模式不同，所以在不同人群开展HIV-1特异性
[Abstract]:Acquired immunodeficiency syndrome (AIDS), the overwhelming majority of the global epidemic caused by the type I human immunodeficiency virus (HIV-1), has become one of the major fatal diseases of human beings. According to the latest estimates of the United Nations AIDS programme and the WHO in 2005, the global sense of the first discovery of HIV-1 infected people since the first discovery in 1981 The total number of infected people is more than 70 million, the number of existing people is 40 million 300 thousand, and the number of infected people is 4 million 900 thousand. High performance antiretroviral therapy (HAART) can reduce the virus content of some patients, delay the development of the disease, improve the symptoms, but because of the high cost, many patients are hard to tolerate the side effects of the drugs and can not be accepted for most patients (especially the development). The more important thing is that HAART can not completely remove the virus. So it is an urgent problem to find an effective HIV-1 vaccine. A large number of studies have shown that cellular immunity, especially the HIV-1 specific CTL response, plays a key role in controlling HIV-1 infection. Great potential. The primary task of developing such vaccines is to determine the specific epitopes that can induce strong HIV-1 specific CTL responses and have extensive immunogenicity. Effective HIV-1 specific CTL responses are not only determined by the antigen structure, but also by the HLA- I allele, which can be seen, screening and identifying the strong and extensive HIV-1 special. The CTL epitopes of the heterosexual epitopes are indispensable to study the HLA- I molecular restriction of the epitopes. The distribution frequency of HLA- I alleles in different populations determines the different CTL response patterns of different populations to HIV-1, so HIV-1 specificity is carried out in different populations.
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R392

【参考文献】