结核分枝杆菌对于异烟肼耐药的分子机制研究进展
发布时间：2018-07-14 20:28
【摘要】：正我国耐药结核病疫情严重,一线抗痨药物异胭肼(INH)作为DOTS(直接督导下短程化疗)战略中重要组成药物已被广泛应用于临床,而长期应用异胭肼可诱导结核分枝杆菌的基因变异,使异胭肼耐药性大幅提高。研究表明结核分枝杆菌中的过氧化氢酶-过氧化物酶(katG)、烯酰脂酰载体蛋白还原酶(inhA)、β-酮酰基酰基运载蛋白合成酶(kasA)、烷基
[Abstract]:As the outbreak of drug-resistant tuberculosis is serious in China, the first-line anti-tuberculosis drug isoparazide (INH) has been widely used in clinical practice as an important component of dots (Direct supervised Short-course chemotherapy) strategy. The gene variation of Mycobacterium tuberculosis could be induced by long term application of iso-hydrazine, and the drug resistance of Mycobacterium tuberculosis could be greatly increased. Studies have shown that catalase peroxidase (katG), (inhA), 尾 -ketoacyl protein synthase (kasA), alkyl in Mycobacterium tuberculosis
【作者单位】： 天津市海河医院;
【分类号】：R346
[Abstract]:As the outbreak of drug-resistant tuberculosis is serious in China, the first-line anti-tuberculosis drug isoparazide (INH) has been widely used in clinical practice as an important component of dots (Direct supervised Short-course chemotherapy) strategy. The gene variation of Mycobacterium tuberculosis could be induced by long term application of iso-hydrazine, and the drug resistance of Mycobacterium tuberculosis could be greatly increased. Studies have shown that catalase peroxidase (katG), (inhA), 尾 -ketoacyl protein synthase (kasA), alkyl in Mycobacterium tuberculosis
【作者单位】： 天津市海河医院;
【分类号】：R346
【参考文献】
相关期刊论文 前5条
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