APOB、GR基因多态性与中国维吾尔族自然长寿的关联研究

发布时间：2018-09-18 21:00

【摘要】：背景：健康长寿是古今中外人们不懈追求的目标，在科学高度发达的今天，已经成为许多学者以毕生精力研究的课题。健康与长寿不仅是生命科学永恒的主题，也是向生命科学提出的终极挑战。当今社会人口老化日益严重，延缓衰老，延长健康期、缩短带病期，提高老年人的生命质量，具有重大的科学意义和社会效益。长寿涉及人类的遗传学、免疫学、基因组学、医学、心理学、营养学等诸多学科，长寿基因是国际学术界公认的长寿根源之一。近年来，随着人类基因组计划的完成和功能基因组学的研究进展，长寿与基因关系的研究倍受关注。目前，研究的焦点多集中在参与脂代谢、能量代谢和机体免疫调控相关的基因，包括胆固醇转运蛋白(CETP)、血管紧张素转换酶(ACE)、抑癌基因(p53)、白细胞介素(IL-6，，IL-10)、胰岛素样生长因子(IGF-I)等基因与长寿的关系，这些基因的共同特点是它们与环境因素相互作用，通过调节机体对疾病的反应性而影响寿命，而并非直接地控制人类的最大寿限。国际自然医学会将新疆和田地区定为世界四大长寿区之一，1990年第四次人口普查显示该地区100岁以上人口高达9.68人／10万人，远高于全国平均水平(0.57人／10万人)。并且，由于环境、生活特点及风俗习惯，居住在该地区的维吾尔族人群极少与外界通婚，人口流动性小，遗传漂变小，极少受医疗因素影响，属自然生存状态，形成了极为难得的遗传隔离群。研究这一特殊的人群，为鉴定长寿的相关
[Abstract]:Background: health and longevity is the goal that people all over the world pursue unremittingly. Today, science is highly developed. It has become a topic that many scholars have devoted their lives to. Health and longevity are not only the eternal theme of life science, but also the ultimate challenge to life science. Nowadays, the aging of population is becoming more and more serious. It is of great scientific and social benefit to delay the aging, prolong the period of health, shorten the period of disease and improve the quality of life of the elderly. Longevity involves human genetics, immunology, genomics, medicine, psychology, nutrition and many other disciplines. Longevity genes are recognized as one of the roots of longevity in international academia. In recent years, with the completion of the Human Genome Project and the progress of functional genomics, the relationship between longevity and genes has attracted much attention. At present, the research focuses on genes involved in lipid metabolism, energy metabolism and immune regulation. Including cholesterol transporter (CETP), angiotensin converting enzyme (ACE), suppressor gene (p53), interleukin (IL-6,IL-10), insulin-like growth factor (IGF-I) and other genes associated with longevity, the common feature of these genes is that they interact with environmental factors. It affects life expectancy by regulating the body's responsiveness to disease, rather than directly controlling the maximum lifespan of humans. In 1990, the fourth census showed that the population over 100 years old in this area was 9.68 / 100000, much higher than the national average (0.57 / 100000). Moreover, because of the environment, living characteristics and customs, the Uygur people living in this area rarely intermarry with the outside world, the population mobility is small, the genetic drift is small, and the medical factors are rarely affected, so it is a natural living state. A rare genetic segregation has been formed. Study of this particular population to identify the association of longevity
【学位授予单位】：新疆医科大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R394

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