lncRNAs参与基因表达调控机制的研究进展

发布时间：2019-08-14 19:41

【摘要】：长链非编码RNAs(long non-coding RNAs,lncRNAs)是一组内源性、长度超过200 nt、缺少特异完整的开放阅读框(open reading frame,ORF)、无或很少有蛋白编码功能的RNAs分子。近年来的研究发现,lncRNAs与许多重要的生物学过程相关,如基因组印记、细胞分化、免疫反应等。lncRNAs在表观遗传水平、转录水平和转录后水平等多个层面调节基因的表达,通过介导染色质重塑和组蛋白修饰、干扰转录、调节选择性剪接模式、生成小RNAs、调节蛋白质活性、改变蛋白质定位等方式,参与机体生长、发育、衰老及死亡等重要生命活动的调控。关于lncRNAs参与基因表达调控的机制有待进一步研究,这将有助于深入理解疾病的发病机制,为寻找疾病分子标记物、药物靶点提供新的方向。
[Abstract]:Long chain non-coding RNAs (long non-coding RNAs,lncRNAs (long chain non-coding RNAs) is a group of RNAs molecules whose length is more than 200 nt, and lacks specific and complete open reading frame (ORF) and has no or little protein coding function. In recent years, it has been found that lncRNAs is related to many important biological processes, such as genomic imprinting, cell differentiation, immune response and so on. IncRNAs regulate gene expression at the apparent genetic level, transcriptional level and post-transcriptional level, regulate transcription by mediating chromatin remodeling and histone modification, interfere with transcription, regulate selective splicing patterns, generate small RNAs, to regulate protein activity, change protein localization, and so on. Participate in the regulation of important life activities such as growth, development, aging and death. The mechanism of lncRNAs involved in gene expression regulation needs to be further studied, which will help to further understand the pathogenesis of disease and provide a new direction for the search for disease molecular markers and drug targets.
【作者单位】：中南大学肿瘤研究所中南大学疾病基因组研究中心卫生部癌变原理重点实验室教育部癌变与侵袭原理重点实验室;国防科技大学信息系统工程重点实验室;中南大学湘雅二医院口腔科;
【基金】：国家自然科学基金(30971147,81071644,81172189,81171930,81272255,81272297,81272298,91229122) 湖南省自然科学基金(10JJ7003) 霍英东高校青年教师基金(121036) 中央高校基本科研业务费专项资金(2011JQ020) 中南大学米塔尔学生创新创业项目(11MX27) 中南大学贵重仪器设备开放共享基金及中南大学博士后科学基金资助项目~~
【分类号】：R346

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