血管紧张素Ⅱ对血管平滑肌细胞中大电导钙激活钾通道的多重调节作用（英文）
发布时间：2021-04-30 21:26
肾素-血管紧张素系统（renin-angiotensin system, RAS）是影响血管平滑肌细胞张力的重要因素。RAS主要活性物质血管紧张素Ⅱ （angiotensin Ⅱ, Ang Ⅱ）可通过激活血管紧张素Ⅱ-1型受体（angiotensin Ⅱ type 1 receptor, AT1R）升高胞内Ca2+浓度,收缩平滑肌细胞。大电导钙激活钾(large-conductance Ca2+-and voltage-activated potassium, BK)通道是血管平滑肌细胞中分布最广、表达最多的钾离子通道,在维持细胞膜电位和胞内钾钙平衡中发挥重要作用。血管平滑肌细胞上的BK通道主要包含α与β1两种亚基。其中功能亚基BKα上分布有膜电位及Ca2+感受器。因此当膜电位或细胞内Ca2+浓度升高时会反馈性引起BK通道开放。然而,越来越多的研究显示,尽管Ang Ⅱ可升高胞内Ca2+浓度,但却通过激活PKC通路、促进AT1R与BKα通道形成的异源二聚体内吞、加快α与β1亚基解...
【文章来源】：生理学报. 2019,71(02)北大核心CSCD
【文章页数】：9 页
【文章目录】：
1 Introduction
2 The structure and function of the BK channel
3 The inhibitory effect of Ang II on the BK channel in VSMCs
3.1 The direct or indirect inhibitory effect of PKC
3.2 Increased endocytosis and degradation of the BK channel
3.3 Down-regulation of BKβ1 subunit
4 The activating effect of Ang II on the BK channel in VSMCs
4.1 The alternative splices of BKαsubunit
4.2 The involvement of AT2 receptor (AT2R)
4.3 The term of Ca2+in activating the BK channel
5 Conclusion and prospect
本文编号：3169505
【文章来源】：生理学报. 2019,71(02)北大核心CSCD
【文章页数】：9 页
【文章目录】：
1 Introduction
2 The structure and function of the BK channel
3 The inhibitory effect of Ang II on the BK channel in VSMCs
3.1 The direct or indirect inhibitory effect of PKC
3.2 Increased endocytosis and degradation of the BK channel
3.3 Down-regulation of BKβ1 subunit
4 The activating effect of Ang II on the BK channel in VSMCs
4.1 The alternative splices of BKαsubunit
4.2 The involvement of AT2 receptor (AT2R)
4.3 The term of Ca2+in activating the BK channel
5 Conclusion and prospect
本文编号：3169505
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