CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation o

发布时间：2021-11-27 16:47

　　Costimulatory signals are crucial for T cell activation. Attempts to block costimulatory pathways have been effective in preventing unwanted immune reactions. In particular, blocking the CD28/cytotoxic T lymphocyte antigen（CTLA）-4/B7 interaction（using CTLA-4Ig） and the CD40/CD40 L interaction（using anti-CD40 L antibodies） prevents T cell mediated autoimmune diseases, transplant rejection and graft vs host disease in experimental models. Moreover, CTLA-4Ig is in clinical use to treat rheumatoid a... 

【文章来源】：World Journal of Immunology. 2014,4(02)

【文章页数】：15 页

【文章目录】：
INTRODUCTION
MECHANISMS OF PERIPHERAL TOLERANCE
    Costimulatory signals
    Regulatory T cells
THE EFFECTS OF BLOCKING COSTIMULATORY SIGNALS
    Blocking the CD28/B7 pathway using CTLA-4Ig
    Blocking the CD40/CD40L pathway
    Combined blockade of the CD28/B7 and the CD40/CD40L pathway
THE ROLE OF TREG CELLS IN IMMUNE SUPPRESSION BY COSTIMULATION BLOCKADE
    Costimulatory requirements of Treg cells
    The effect of CD40/CD40L blockade on Treg cells
    The effect of CTLA-4Ig on Treg cells
CONCLUSION



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