医院获得性铜绿假单胞菌血流感染临床特征及死亡危险因素分析

发布时间：2017-12-28 05:11

本文关键词：医院获得性铜绿假单胞菌血流感染临床特征及死亡危险因素分析　出处：《解放军医学院学报》2016年04期 　论文类型：期刊论文

【摘要】：目的探讨医院获得性铜绿假单胞菌血流感染患者的临床特征及死亡危险因素,为临床救治提供依据。方法收集本院2010年1月-2014年12月医院获得性铜绿假单胞菌血流感染患者的临床资料,对其临床特点和死亡危险因素进行回顾性分析。结果 136例患者入选本研究,其中男性96例,女性40例,平均年龄为(52.9±23.36)岁。130例(95.59%)发热,86例(63.24%)伴寒战;100例(73.52%)白细胞升高或减少,121例(88.97%)C反应蛋白升高。32例死亡,病死率23.53%,死亡单因素分析显示,年龄70岁、APACHEⅡ评分、肺部感染、入住ICU、有创机械通气、多重耐药、血红蛋白90g/L和白蛋白35 g/L与死亡相关;Logistic回归分析显示,APACHEⅡ评分、有创机械通气为死亡独立危险因素。结论发热、寒战、白细胞升高或减少、C反应蛋白升高等为医院获得性铜绿假单胞菌血流感染的主要临床特征;高APACHEⅡ评分、有创机械通气为其死亡独立危险因素。
[Abstract]:Objective to investigate the clinical characteristics and death risk factors of the patients with hospital acquired Pseudomonas aeruginosa blood flow infection, and to provide the basis for clinical treatment. Methods the clinical data of hospital acquired Pseudomonas aeruginosa bloodstream infections in our hospital from January 2010 to December -2014 were collected, and the clinical characteristics and risk factors of death were retrospectively analyzed. Results 136 patients were enrolled in this study, among which 96 cases were male, 40 were female, the average age was (52.9 + 23.36) years old. 130 cases (95.59%) had fever, 86 cases (63.24%) accompanied chill, 100 (73.52%) leucocyte increased or decreased, and 121 (88.97%) C reaction protein increased. 32 cases died, the mortality rate was 23.53%, the death of the single factor analysis showed that the age of 70, APACHE score, pulmonary infection, ICU stay, invasive mechanical ventilation, multidrug resistance, hemoglobin 90g/L and albumin in 35 g/L associated with death; Logistic regression analysis showed that APACHE score, mechanical ventilation were independent risk factors for death. Conclusion fever, chills, leukocyte increase or decrease, and elevated C reactive protein are the main clinical characteristics of hospital acquired Pseudomonas aeruginosa bloodstream infections. High APACHE II score and invasive mechanical ventilation are independent risk factors for death.
【作者单位】：解放军总医院呼吸科;
【基金】：总后卫生部-部队卫生与疾病防控应用性研究项目(13B JYZ32)~~
【分类号】：R515.3
【正文快照】： 铜绿假单胞菌已经成为医院感染的主要致病菌之一[1],文献报道其占血流感染的2.81%~8.0%[2-4]。发生血流感染的病人往往病情重,住院时间长,病死率高,给临床诊治带来极大挑战。为了提高该病诊治的成功率,本文收集了我院院内获得性铜绿假单胞菌血流感染患者的临床资料,并对其临床

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