HCV不同基因型对慢性丙型肝炎抗病毒治疗疗效的影响

发布时间：2018-01-05 18:22

本文关键词：HCV不同基因型对慢性丙型肝炎抗病毒治疗疗效的影响　出处：《北华大学学报(自然科学版)》2016年04期 　论文类型：期刊论文

【摘要】：目的探讨干扰素联合利巴韦林治疗慢性丙型肝炎患者临床疗效的相关影响因素.方法对110例慢性丙型肝炎患者进行PEG-IFNα-2a 180μg/周联合RBV 800~1200 mg/d的标准治疗,并完成治疗后24周随访,同时分析HCV基因型、HCV-RNA定量对持续病毒学应答(SVR)的影响.应用罗氏试剂检测丙肝病毒定量,应用反转录-套式聚合酶链反应(PT-PCR)法检测HCV基因型.结果在110例进行标准联合治疗、并完成治疗后24周随访的慢性丙型肝炎患者中,68例患者获得SVR.其中,HCV基因1b型感染者SVR率为51.4%(37/72),HCV基因N-1b型感染者SVR率为81.5%(31/38);基线HCV-RNA水平1.0×10~5IU/m L的患者SVR率为71.2%(42/59),基线HCV-RNA水平≥1.0×10~5IU/m L的患者SVR率为50.9%(26/51).结论非1b基因型SVR率高于1b基因型;基线低病毒RNA水平(血清HCV-RNA水平1.0×10~5IU/m L)SVR率高于基线高病毒RNA水平(血清HCV-RNA水平≥1.0×10~5IU/m L).
[Abstract]:Objective to study the influencing factors of interferon combined with Leigh Bhave Lin for the treatment of chronic hepatitis C patients. The standard treatment of PEG-IFN alpha -2a 180 g/ RBV 800~1200 mg/d week on 110 patients with chronic hepatitis C, and 24 weeks after treatment and follow-up analysis of genotype HCV, HCV-RNA quantitative of sustained virological response (SVR). The effects of application of quantitative detection of hepatitis C virus Roche reagent, application of reverse transcription nested polymerase chain reaction (PT-PCR) method to detect HCV genotype. The standard combination therapy in 110 cases of patients with chronic hepatitis C and 24 weeks after the completion of treatment, 68 patients achieved SVR., HCV genotype 1b infection the SVR rate was 51.4% (37/72), HCV genotype N-1b infection rate of SVR was 81.5% (31/38); the baseline level of HCV-RNA 1 * 10~5IU/m L with SVR rate was 71.2% (42/59), baseline HCV-RNA levels over 1 * 10~5IU/ M L with SVR rate was 50.9% (26/51). Conclusion 1b genotype SVR was higher than that of the 1b genotype; HBV RNA levels (low baseline serum HCV-RNA levels of 1 x 10~5IU/m L) SVR rate is higher than the baseline level of RNA virus (high serum HCV-RNA level over 1 * 10~5IU/m L).

【作者单位】：北华大学肝病研究所;
【基金】：吉林省卫计委基金项目(2013z056)
【分类号】：R512.63
【正文快照】： 【引用格式】王瑶,孙亚臣,王爱平,等.HCV不同基因型对慢性丙型肝炎抗病毒治疗疗效的影响[J].北华大学学报(自然科学版),2016,17(4):524-526.丙型肝炎病毒(hepatitis C virus,HCV)感染可引起肝脏的急慢性炎症,全世界范围内约有1.7亿人感染HCV[1],我国感染者约有4 200万人,属HCV

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